Comparison of Genetic Risk Factors Between Two Type II Diabetes Subtypes

Persistent Link:
http://hdl.handle.net/10150/595048
Title:
Comparison of Genetic Risk Factors Between Two Type II Diabetes Subtypes
Author:
Schader, Lindsey Marie
Issue Date:
2015
Publisher:
The University of Arizona.
Rights:
Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
Abstract:
Type 2 Diabetes (T2D) is an extremely heterogeneous disease, and the heritability of T2D is not fully accounted for. This study seeks to determine T2D subtypes based on clinical features before T2D diagnosis, and to test whether genetic risk factors differ between the subtypes. A sample of 13,459 White, GWAS study participants was obtained from FRAM, MESA, and ARIC. This sample consisted of 832 cases (individuals who developed T2D during follow-up) and 12,066 controls (did not develop T2D). K-means clustering was used to cluster individuals in the cases dataset based on metabolic and anthropometric characteristics. Cox proportional hazards models were used to test whether T2D genetic risk factors differed between the groups. The clustering analysis resulted in two clusters with cluster one consisting of a higher percentage of women with higher WHR, lower HDL, and higher FI as compared to cluster two. There were no statistically significant differences between the genetic risk factors of the two clusters. The most significant differences in genetic risk factors were associated with adiposity, suggesting some interaction between adiposity genes and the characteristic phenotypes of each cluster on T2D development. Further research is needed to replicate subtypes and to find significant genetic associations.
Type:
text; Electronic Thesis
Degree Name:
B.S.
Degree Level:
bachelors
Degree Program:
Honors College; Biology
Degree Grantor:
University of Arizona
Advisor:
Klimentidis, Yann

Full metadata record

DC FieldValue Language
dc.language.isoen_USen
dc.titleComparison of Genetic Risk Factors Between Two Type II Diabetes Subtypesen_US
dc.creatorSchader, Lindsey Marieen
dc.contributor.authorSchader, Lindsey Marieen
dc.date.issued2015en
dc.publisherThe University of Arizona.en
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.en
dc.description.abstractType 2 Diabetes (T2D) is an extremely heterogeneous disease, and the heritability of T2D is not fully accounted for. This study seeks to determine T2D subtypes based on clinical features before T2D diagnosis, and to test whether genetic risk factors differ between the subtypes. A sample of 13,459 White, GWAS study participants was obtained from FRAM, MESA, and ARIC. This sample consisted of 832 cases (individuals who developed T2D during follow-up) and 12,066 controls (did not develop T2D). K-means clustering was used to cluster individuals in the cases dataset based on metabolic and anthropometric characteristics. Cox proportional hazards models were used to test whether T2D genetic risk factors differed between the groups. The clustering analysis resulted in two clusters with cluster one consisting of a higher percentage of women with higher WHR, lower HDL, and higher FI as compared to cluster two. There were no statistically significant differences between the genetic risk factors of the two clusters. The most significant differences in genetic risk factors were associated with adiposity, suggesting some interaction between adiposity genes and the characteristic phenotypes of each cluster on T2D development. Further research is needed to replicate subtypes and to find significant genetic associations.en
dc.typetexten
dc.typeElectronic Thesisen
thesis.degree.nameB.S.en
thesis.degree.levelbachelorsen
thesis.degree.disciplineHonors Collegeen
thesis.degree.disciplineBiologyen
thesis.degree.grantorUniversity of Arizonaen
dc.contributor.advisorKlimentidis, Yannen
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