Persistent Link:
http://hdl.handle.net/10150/595047
Title:
The Effects of Age on External Cue-Based Spatial Navigation
Author:
Koutia, Adele Janette
Issue Date:
2015
Publisher:
The University of Arizona.
Rights:
Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
Abstract:
As animals age, there are functional alterations in synaptic connectivity and plasticity within the hippocampus and the entorhinal cortex. These changes are associated with age-related spatial memory deficits. Importantly, there is evidence that at least in some experimental situations aged rats may rely on self-motion information more than external visual cues for navigation. In order to better understand differences in the degree to which old and young animals are able to utilize external cues to update their internal representations of space a novel behavioral apparatus was developed to allow for complete and immediate control of all visual cues in the environment. Both old and young rats were able to locate a goal location after all orienting cues in the apparatus were rotated instantaneously. Unexpectedly, aged animals tended to change their behavior to realign with the rotated cues more reliably than did young animals. Young rats tended to visit the area surrounding the goal location, but appeared to improve over time.
Type:
text; Electronic Thesis
Degree Name:
B.S.
Degree Level:
bachelors
Degree Program:
Honors College; Neuroscience and Cognitive Science
Degree Grantor:
University of Arizona
Advisor:
Barnes, Carol A.

Full metadata record

DC FieldValue Language
dc.language.isoen_USen
dc.titleThe Effects of Age on External Cue-Based Spatial Navigationen_US
dc.creatorKoutia, Adele Janetteen
dc.contributor.authorKoutia, Adele Janetteen
dc.date.issued2015en
dc.publisherThe University of Arizona.en
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.en
dc.description.abstractAs animals age, there are functional alterations in synaptic connectivity and plasticity within the hippocampus and the entorhinal cortex. These changes are associated with age-related spatial memory deficits. Importantly, there is evidence that at least in some experimental situations aged rats may rely on self-motion information more than external visual cues for navigation. In order to better understand differences in the degree to which old and young animals are able to utilize external cues to update their internal representations of space a novel behavioral apparatus was developed to allow for complete and immediate control of all visual cues in the environment. Both old and young rats were able to locate a goal location after all orienting cues in the apparatus were rotated instantaneously. Unexpectedly, aged animals tended to change their behavior to realign with the rotated cues more reliably than did young animals. Young rats tended to visit the area surrounding the goal location, but appeared to improve over time.en
dc.typetexten
dc.typeElectronic Thesisen
thesis.degree.nameB.S.en
thesis.degree.levelbachelorsen
thesis.degree.disciplineHonors Collegeen
thesis.degree.disciplineNeuroscience and Cognitive Scienceen
thesis.degree.grantorUniversity of Arizonaen
dc.contributor.advisorBarnes, Carol A.en
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