Foamy-like Endogenous Retroviruses Are Abundant and Extensive In Teleosts

Persistent Link:
http://hdl.handle.net/10150/594955
Title:
Foamy-like Endogenous Retroviruses Are Abundant and Extensive In Teleosts
Author:
Ruboyianes, Ryan
Issue Date:
2015
Publisher:
The University of Arizona.
Rights:
Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
Embargo:
Release 15-Jun-2016
Abstract:
Spumaretrovirus, among retrovirus clades, has an extensive accumulation of evidence for an ancient origin. Recent discoveries indicate that the Spumaretrovirus ancestor could have been the first retrovirus to appear during the evolution of vertebrates. If they indeed appeared in ancient marine environments hundreds of millions of years ago, we should expect significant undiscovered diversity of foamy-like endogenous retroviruses in fish genomes. I report the discovery of these elements in 23 novel teleost hosts. These viruses have very large genomes compared to all other retroviruses, possess an unprecedented array of accessory genes, and form a robust reciprocally monophyletic sister clade with sarcopterygian host foamy viruses, with class III mammal endogenous retroviruses being the immediate sister group to both clades. I estimated that some of these viruses integrated recently into host genomes, and exogenous descendants of these viruses may be extant.
Type:
text; Electronic Thesis
Keywords:
Ecology & Evolutionary Biology
Degree Name:
M.S.
Degree Level:
masters
Degree Program:
Graduate College; Ecology & Evolutionary Biology
Degree Grantor:
University of Arizona
Advisor:
Worobey, Michael

Full metadata record

DC FieldValue Language
dc.language.isoen_USen
dc.titleFoamy-like Endogenous Retroviruses Are Abundant and Extensive In Teleostsen_US
dc.creatorRuboyianes, Ryanen
dc.contributor.authorRuboyianes, Ryanen
dc.date.issued2015en
dc.publisherThe University of Arizona.en
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.en
dc.description.releaseRelease 15-Jun-2016en
dc.description.abstractSpumaretrovirus, among retrovirus clades, has an extensive accumulation of evidence for an ancient origin. Recent discoveries indicate that the Spumaretrovirus ancestor could have been the first retrovirus to appear during the evolution of vertebrates. If they indeed appeared in ancient marine environments hundreds of millions of years ago, we should expect significant undiscovered diversity of foamy-like endogenous retroviruses in fish genomes. I report the discovery of these elements in 23 novel teleost hosts. These viruses have very large genomes compared to all other retroviruses, possess an unprecedented array of accessory genes, and form a robust reciprocally monophyletic sister clade with sarcopterygian host foamy viruses, with class III mammal endogenous retroviruses being the immediate sister group to both clades. I estimated that some of these viruses integrated recently into host genomes, and exogenous descendants of these viruses may be extant.en
dc.typetexten
dc.typeElectronic Thesisen
dc.subjectEcology & Evolutionary Biologyen
thesis.degree.nameM.S.en
thesis.degree.levelmastersen
thesis.degree.disciplineGraduate Collegeen
thesis.degree.disciplineEcology & Evolutionary Biologyen
thesis.degree.grantorUniversity of Arizonaen
dc.contributor.advisorWorobey, Michaelen
dc.contributor.committeememberWorobey, Michaelen
dc.contributor.committeememberBarker, Michael S.en
dc.contributor.committeememberWiens, John J.en
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