The Effects of the Insulin Signaling Pathway on TDP-43 Toxicity in Amyotrophic Lateral Sclerosis

Persistent Link:
http://hdl.handle.net/10150/579314
Title:
The Effects of the Insulin Signaling Pathway on TDP-43 Toxicity in Amyotrophic Lateral Sclerosis
Author:
Riffer, Michelle Kori
Issue Date:
2015
Publisher:
The University of Arizona.
Rights:
Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
Abstract:
The causes of Amyotrophic Lateral Sclerosis, a fatal neurodegenerative disease that results in skeletal muscle paralysis, are not clear; however, the nuclear RNA-binding protein TDP-43 has been suggested to play a critical role in ALS pathology. A previous drug screen that demonstrated lethality rescue in flies administered anti-diabetic drugs hinted that perhaps the Insulin signaling pathway in motor neurons might be mediating TDP-43 toxicity. Therefore, our original hypothesis was simple in that we reasoned that the insulin pathway was interacting with TDP-43. Eventually, our larval turning, lethality and eye phenotype assays have allowed us to further hypothesize that insulin resistance in motor neurons is contributing to TDP-43 neurotoxicity.
Type:
text; Electronic Thesis
Degree Name:
B.S.
Degree Level:
bachelors
Degree Program:
Honors College; Molecular and Cellular Biology
Degree Grantor:
University of Arizona
Advisor:
Zarnescu, Daniela C.

Full metadata record

DC FieldValue Language
dc.language.isoen_USen
dc.titleThe Effects of the Insulin Signaling Pathway on TDP-43 Toxicity in Amyotrophic Lateral Sclerosisen_US
dc.creatorRiffer, Michelle Korien
dc.contributor.authorRiffer, Michelle Korien
dc.date.issued2015en
dc.publisherThe University of Arizona.en
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.en
dc.description.abstractThe causes of Amyotrophic Lateral Sclerosis, a fatal neurodegenerative disease that results in skeletal muscle paralysis, are not clear; however, the nuclear RNA-binding protein TDP-43 has been suggested to play a critical role in ALS pathology. A previous drug screen that demonstrated lethality rescue in flies administered anti-diabetic drugs hinted that perhaps the Insulin signaling pathway in motor neurons might be mediating TDP-43 toxicity. Therefore, our original hypothesis was simple in that we reasoned that the insulin pathway was interacting with TDP-43. Eventually, our larval turning, lethality and eye phenotype assays have allowed us to further hypothesize that insulin resistance in motor neurons is contributing to TDP-43 neurotoxicity.en
dc.typetexten
dc.typeElectronic Thesisen
thesis.degree.nameB.S.en
thesis.degree.levelbachelorsen
thesis.degree.disciplineHonors Collegeen
thesis.degree.disciplineMolecular and Cellular Biologyen
thesis.degree.grantorUniversity of Arizonaen
dc.contributor.advisorZarnescu, Daniela C.en
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