Persistent Link:
http://hdl.handle.net/10150/579262
Title:
Computational Analysis of the Control of Cell Cycle Entry
Author:
Everetts, Nicholas John
Issue Date:
2015
Publisher:
The University of Arizona.
Rights:
Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
Abstract:
The reactivation of quiescent cells (e.g. stem cells) into proliferation is a crucial process for tissue repair and regeneration. The start of cell proliferation from quiescence is dependent on a "bistable" Rb-E2F gene pathway. The bistable nature allows the Rb-E2F pathway, in response to serum growth signals, to exist in two distinct states: an E2F-OFF/quiescence state and an E2F-ON/ proliferation state. In 2008, Yao at al. derived a mathematical model that predicts the effects of serum stimulation on the Rb-E2F pathway. The research described in this paper involved altering the values of model parameters (corresponding to individual gene regulation events) systematically to understand how cellular factors affect the serum threshold to activate the Rb-E2F bistable switch. Many of the model parameters that displayed the highest sensitivity on the OFF-to-ON serum threshold of the Rb-E2F model were involved with cyclin D activity. In addition, the model was used to predict the time required for cell to reach the R-point under a variety of stimulant conditions and gene mutations.
Type:
text; Electronic Thesis
Degree Name:
B.S.
Degree Level:
bachelors
Degree Program:
Honors College; Biochemistry
Degree Grantor:
University of Arizona
Advisor:
Yao, Guang

Full metadata record

DC FieldValue Language
dc.language.isoen_USen
dc.titleComputational Analysis of the Control of Cell Cycle Entryen_US
dc.creatorEveretts, Nicholas Johnen
dc.contributor.authorEveretts, Nicholas Johnen
dc.date.issued2015en
dc.publisherThe University of Arizona.en
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.en
dc.description.abstractThe reactivation of quiescent cells (e.g. stem cells) into proliferation is a crucial process for tissue repair and regeneration. The start of cell proliferation from quiescence is dependent on a "bistable" Rb-E2F gene pathway. The bistable nature allows the Rb-E2F pathway, in response to serum growth signals, to exist in two distinct states: an E2F-OFF/quiescence state and an E2F-ON/ proliferation state. In 2008, Yao at al. derived a mathematical model that predicts the effects of serum stimulation on the Rb-E2F pathway. The research described in this paper involved altering the values of model parameters (corresponding to individual gene regulation events) systematically to understand how cellular factors affect the serum threshold to activate the Rb-E2F bistable switch. Many of the model parameters that displayed the highest sensitivity on the OFF-to-ON serum threshold of the Rb-E2F model were involved with cyclin D activity. In addition, the model was used to predict the time required for cell to reach the R-point under a variety of stimulant conditions and gene mutations.en
dc.typetexten
dc.typeElectronic Thesisen
thesis.degree.nameB.S.en
thesis.degree.levelbachelorsen
thesis.degree.disciplineHonors Collegeen
thesis.degree.disciplineBiochemistryen
thesis.degree.grantorUniversity of Arizonaen
dc.contributor.advisorYao, Guangen
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