An Investigation of Cellular Proliferation and Nuclear Morphology in the Multi-Step Progression of Cutaneous Squamous Cell Carcinoma

Persistent Link:
http://hdl.handle.net/10150/579258
Title:
An Investigation of Cellular Proliferation and Nuclear Morphology in the Multi-Step Progression of Cutaneous Squamous Cell Carcinoma
Author:
Kha, Stephanie Tieu
Issue Date:
2015
Publisher:
The University of Arizona.
Rights:
Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
Abstract:
With 3.5 million cases diagnosed in more than 2 million people in the United States annually, skin cancer leads as a frequent and devastating disease carrying a large public health burden. Understanding the multi-step disease progression is crucial for developing interventional strategies that can reduce the incidence as well as the risk of recurrence for non-melanoma skin cancers. In this study of 40 tissue samples, cellular proliferation is quantified and analyzed in four categories that represent the stages of progression for SCC carcinogenesis: Normal, Sun-exposed, Actinic Keratosis, and Squamous Cell Carcinoma. The results in this study show an exponential increase in levels of Proliferative Cell Nuclear Antigen (PCNA) expression with each progressed category, as well as a positive association with nuclear morphology feature values related to sun-damaged nuclei that were published in a previous study. These findings support the utility of investigative techniques from the field of immunohistochemistry in studying the UV-induced skin carcinogenesis model for the multi-step disease progression of cutaneous squamous cell carcinoma. Furthermore, this study elucidates the complexities involved in clinical histological diagnoses for non-melanoma skin cancers.
Type:
text; Electronic Thesis
Degree Name:
B.S.
Degree Level:
bachelors
Degree Program:
Honors College; Biochemistry
Degree Grantor:
University of Arizona
Advisor:
Alberts, David S.; Einspahr, Janine; Miesfeld, Roger

Full metadata record

DC FieldValue Language
dc.language.isoen_USen
dc.titleAn Investigation of Cellular Proliferation and Nuclear Morphology in the Multi-Step Progression of Cutaneous Squamous Cell Carcinomaen_US
dc.creatorKha, Stephanie Tieuen
dc.contributor.authorKha, Stephanie Tieuen
dc.date.issued2015en
dc.publisherThe University of Arizona.en
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.en
dc.description.abstractWith 3.5 million cases diagnosed in more than 2 million people in the United States annually, skin cancer leads as a frequent and devastating disease carrying a large public health burden. Understanding the multi-step disease progression is crucial for developing interventional strategies that can reduce the incidence as well as the risk of recurrence for non-melanoma skin cancers. In this study of 40 tissue samples, cellular proliferation is quantified and analyzed in four categories that represent the stages of progression for SCC carcinogenesis: Normal, Sun-exposed, Actinic Keratosis, and Squamous Cell Carcinoma. The results in this study show an exponential increase in levels of Proliferative Cell Nuclear Antigen (PCNA) expression with each progressed category, as well as a positive association with nuclear morphology feature values related to sun-damaged nuclei that were published in a previous study. These findings support the utility of investigative techniques from the field of immunohistochemistry in studying the UV-induced skin carcinogenesis model for the multi-step disease progression of cutaneous squamous cell carcinoma. Furthermore, this study elucidates the complexities involved in clinical histological diagnoses for non-melanoma skin cancers.en
dc.typetexten
dc.typeElectronic Thesisen
thesis.degree.nameB.S.en
thesis.degree.levelbachelorsen
thesis.degree.disciplineHonors Collegeen
thesis.degree.disciplineBiochemistryen
thesis.degree.grantorUniversity of Arizonaen
dc.contributor.advisorAlberts, David S.en
dc.contributor.advisorEinspahr, Janineen
dc.contributor.advisorMiesfeld, Rogeren
All Items in UA Campus Repository are protected by copyright, with all rights reserved, unless otherwise indicated.