Investigating Meningeal Ion Channels As New Molecular Targets For Migraine

Persistent Link:
http://hdl.handle.net/10150/565832
Title:
Investigating Meningeal Ion Channels As New Molecular Targets For Migraine
Author:
Wei, Xiaomei
Issue Date:
2014
Publisher:
The University of Arizona.
Rights:
Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
Abstract:
This dissertation will present the four manuscripts I published or am ready to publish on the study of the pathophysiology of migraine headache. The first chapter will discuss the background of the current understanding of migraine pathophysiology. Chapter 2 is focused on studying how Transient receptor potential vanilloid 4 (TRPV4) might play a role in migraine headache. Chapter 3 is the study of a novel cell type: dural fibroblasts might also play an active role in migraine headache. Chapter 4 is discussing Norepinephrine's role in headache pathophysiology. Chapter 5 is studying the combined effect of Acid and ATP in the pathophysiology of migraine headache. The dissertation will end in a conclusion in Chapter 6.
Type:
text; Electronic Dissertation
Keywords:
Dural fibroblasts; Ion Channel; Migraine; NE; TRPV4; Medical Pharmacology; ASIC
Degree Name:
Ph.D.
Degree Level:
doctoral
Degree Program:
Graduate College; Medical Pharmacology
Degree Grantor:
University of Arizona
Advisor:
Drussor, Gregory

Full metadata record

DC FieldValue Language
dc.language.isoen_USen
dc.titleInvestigating Meningeal Ion Channels As New Molecular Targets For Migraineen_US
dc.creatorWei, Xiaomeien
dc.contributor.authorWei, Xiaomeien
dc.date.issued2014en
dc.publisherThe University of Arizona.en
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.en
dc.description.abstractThis dissertation will present the four manuscripts I published or am ready to publish on the study of the pathophysiology of migraine headache. The first chapter will discuss the background of the current understanding of migraine pathophysiology. Chapter 2 is focused on studying how Transient receptor potential vanilloid 4 (TRPV4) might play a role in migraine headache. Chapter 3 is the study of a novel cell type: dural fibroblasts might also play an active role in migraine headache. Chapter 4 is discussing Norepinephrine's role in headache pathophysiology. Chapter 5 is studying the combined effect of Acid and ATP in the pathophysiology of migraine headache. The dissertation will end in a conclusion in Chapter 6.en
dc.typetexten
dc.typeElectronic Dissertationen
dc.subjectDural fibroblastsen
dc.subjectIon Channelen
dc.subjectMigraineen
dc.subjectNEen
dc.subjectTRPV4en
dc.subjectMedical Pharmacologyen
dc.subjectASICen
thesis.degree.namePh.D.en
thesis.degree.leveldoctoralen
thesis.degree.disciplineGraduate Collegeen
thesis.degree.disciplineMedical Pharmacologyen
thesis.degree.grantorUniversity of Arizonaen
dc.contributor.advisorDrussor, Gregoryen
dc.contributor.committeememberDrussor, Gregoryen
dc.contributor.committeememberPrice, Theodoreen
dc.contributor.committeememberPorreca, Franken
dc.contributor.committeememberVanderah, Todd W.en
dc.contributor.committeememberGhosh, Souraven
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