Preformulation of Topical Chemopreventive Agents and the Solubility Estimation of Hydrated Solutes

Persistent Link:
http://hdl.handle.net/10150/556882
Title:
Preformulation of Topical Chemopreventive Agents and the Solubility Estimation of Hydrated Solutes
Author:
Franklin, Stephen J.
Issue Date:
2015
Publisher:
The University of Arizona.
Rights:
Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
Abstract:
Preformulation studies of two naturally occurring compounds, sulforaphane and myricetin, are presented. Both compounds have shown promise as chemoprevention agents throughout the literature. Despite this evidence, minimal information is available to guide the progression of formulations designed for future drug development. The presented work describes solubility, stability, and solid-state characterization of these compounds. Additionally, a mathematical model based on the ideal solubility equation, which reasonably estimates the solubility of a hydrate is described. This model accounts for the dehydration energetics of the solute as it transforms from hydrate to anhydrous prior to melting and conversion to a hypothetical super-cooled liquid (HSL). This model will lend itself to the appreciation of the solubility differences that can exist between hydrate and anhydrous drug forms. By improving the accuracy of solubility estimation, drug development studies involving hydrates can be designed more accurately.
Type:
text; Electronic Dissertation
Keywords:
Preformulation; Solubility Estimation; Topical Delivery; Pharmaceutical Sciences; Hydrates
Degree Name:
Ph.D.
Degree Level:
doctoral
Degree Program:
Graduate College; Pharmaceutical Sciences
Degree Grantor:
University of Arizona
Advisor:
Myrdal, Paul B.

Full metadata record

DC FieldValue Language
dc.language.isoen_USen
dc.titlePreformulation of Topical Chemopreventive Agents and the Solubility Estimation of Hydrated Solutesen_US
dc.creatorFranklin, Stephen J.en
dc.contributor.authorFranklin, Stephen J.en
dc.date.issued2015en
dc.publisherThe University of Arizona.en
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.en
dc.description.abstractPreformulation studies of two naturally occurring compounds, sulforaphane and myricetin, are presented. Both compounds have shown promise as chemoprevention agents throughout the literature. Despite this evidence, minimal information is available to guide the progression of formulations designed for future drug development. The presented work describes solubility, stability, and solid-state characterization of these compounds. Additionally, a mathematical model based on the ideal solubility equation, which reasonably estimates the solubility of a hydrate is described. This model accounts for the dehydration energetics of the solute as it transforms from hydrate to anhydrous prior to melting and conversion to a hypothetical super-cooled liquid (HSL). This model will lend itself to the appreciation of the solubility differences that can exist between hydrate and anhydrous drug forms. By improving the accuracy of solubility estimation, drug development studies involving hydrates can be designed more accurately.en
dc.typetexten
dc.typeElectronic Dissertationen
dc.subjectPreformulationen
dc.subjectSolubility Estimationen
dc.subjectTopical Deliveryen
dc.subjectPharmaceutical Sciencesen
dc.subjectHydratesen
thesis.degree.namePh.D.en
thesis.degree.leveldoctoralen
thesis.degree.disciplineGraduate Collegeen
thesis.degree.disciplinePharmaceutical Sciencesen
thesis.degree.grantorUniversity of Arizonaen
dc.contributor.advisorMyrdal, Paul B.en
dc.contributor.committeememberMyrdal, Paul B.en
dc.contributor.committeememberMansour, Heidien
dc.contributor.committeememberMayersohn, Michaelen
dc.contributor.committeememberYalkowsky, Samuel H.en
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