Fisher Information in X-ray/Gamma-ray Imaging Instrumentation Design

Persistent Link:
http://hdl.handle.net/10150/556861
Title:
Fisher Information in X-ray/Gamma-ray Imaging Instrumentation Design
Author:
Salcin, Esen
Issue Date:
2015
Publisher:
The University of Arizona.
Rights:
Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
Embargo:
Release after 31-Dec-2016
Abstract:
Signal formation in a photon-counting x-ray/gamma-ray imaging detector is a complex process resulting in detector signals governed by multiple random effects. Recovering maximum possible information about event attributes of interest requires a systematic collection of calibration data and analysis provided by estimation theory. In this context, a likelihood model provides a description of the connection between the observed signals and the event attributes. A quantitative measure of how well the measured signals can be used to produce an estimate of the parameters is given by Fisher Information analysis. In this work, we demonstrate several applications of the Fisher Information Matrix (FIM) as a powerful and practical tool for investigating and optimizing potential next-generation x-ray/gamma-ray detector designs, with an emphasis on medical-imaging applications. Using FIM as a design tool means to explore the physical detector design choices that have a relationship with the FIM through the likelihood function, how are they interrelated, and determining whether it is possible to modify any of these choices to yield or retain higher values for Fisher Information. We begin by testing these ideas by investigating a new type of a semiconductor detector, a Cadmium Telluride (CdTe) detector with double-sided-strip geometry developed by our collaborators at the Japan Aerospace Exploration Agency (JAXA). The statistical properties of the detector signals as a function of interaction positions in 3D (x, y, z) are presented with mathematical expressions as well as experimental data from measurements using synchrotron radiation at the Advanced Photon Source at Argonne National Laboratory. We show the computation of FIM for evaluating positioning performance and discuss how various detector parameters, that are identified to affect FIM, can be used in detector optimization. Next, we show the application of FIM analysis in a detector system based on multi-anode photomultiplier tubes coupled to a monolithic scintillator in the design of smart electronic read-out strategies. We conclude by arguing that a detector system is expected to perform the best when the hardware is optimized jointly with the estimation algorithm (simply referred to as the "software" in this context) that will be used with it. The results of this work lead to the idea of a detector development approach where the detector hardware platform is developed concurrently with the software and firmware in order to achieve optimal performance.
Type:
text; Electronic Dissertation
Keywords:
Crossed-strip; Detector; Fisher Information; SPECT; Optical Sciences; CdTe
Degree Name:
Ph.D.
Degree Level:
doctoral
Degree Program:
Graduate College; Optical Sciences
Degree Grantor:
University of Arizona
Advisor:
Furenlid, Lars R.

Full metadata record

DC FieldValue Language
dc.language.isoen_USen
dc.titleFisher Information in X-ray/Gamma-ray Imaging Instrumentation Designen_US
dc.creatorSalcin, Esenen
dc.contributor.authorSalcin, Esenen
dc.date.issued2015en
dc.publisherThe University of Arizona.en
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.en
dc.description.releaseRelease after 31-Dec-2016en
dc.description.abstractSignal formation in a photon-counting x-ray/gamma-ray imaging detector is a complex process resulting in detector signals governed by multiple random effects. Recovering maximum possible information about event attributes of interest requires a systematic collection of calibration data and analysis provided by estimation theory. In this context, a likelihood model provides a description of the connection between the observed signals and the event attributes. A quantitative measure of how well the measured signals can be used to produce an estimate of the parameters is given by Fisher Information analysis. In this work, we demonstrate several applications of the Fisher Information Matrix (FIM) as a powerful and practical tool for investigating and optimizing potential next-generation x-ray/gamma-ray detector designs, with an emphasis on medical-imaging applications. Using FIM as a design tool means to explore the physical detector design choices that have a relationship with the FIM through the likelihood function, how are they interrelated, and determining whether it is possible to modify any of these choices to yield or retain higher values for Fisher Information. We begin by testing these ideas by investigating a new type of a semiconductor detector, a Cadmium Telluride (CdTe) detector with double-sided-strip geometry developed by our collaborators at the Japan Aerospace Exploration Agency (JAXA). The statistical properties of the detector signals as a function of interaction positions in 3D (x, y, z) are presented with mathematical expressions as well as experimental data from measurements using synchrotron radiation at the Advanced Photon Source at Argonne National Laboratory. We show the computation of FIM for evaluating positioning performance and discuss how various detector parameters, that are identified to affect FIM, can be used in detector optimization. Next, we show the application of FIM analysis in a detector system based on multi-anode photomultiplier tubes coupled to a monolithic scintillator in the design of smart electronic read-out strategies. We conclude by arguing that a detector system is expected to perform the best when the hardware is optimized jointly with the estimation algorithm (simply referred to as the "software" in this context) that will be used with it. The results of this work lead to the idea of a detector development approach where the detector hardware platform is developed concurrently with the software and firmware in order to achieve optimal performance.en
dc.typetexten
dc.typeElectronic Dissertationen
dc.subjectCrossed-stripen
dc.subjectDetectoren
dc.subjectFisher Informationen
dc.subjectSPECTen
dc.subjectOptical Sciencesen
dc.subjectCdTeen
thesis.degree.namePh.D.en
thesis.degree.leveldoctoralen
thesis.degree.disciplineGraduate Collegeen
thesis.degree.disciplineOptical Sciencesen
thesis.degree.grantorUniversity of Arizonaen
dc.contributor.advisorFurenlid, Lars R.en
dc.contributor.committeememberBarrett, Harrison H.en
dc.contributor.committeememberBarber, H. Bradforden
dc.contributor.committeememberKupinski, Matthew A.en
dc.contributor.committeememberFurenlid, Lars R.en
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