System and Method for Comparison and Training of Mechanical Circulatory Support Devices: A Patient Independent Platform Using the Total Artificial Heart and Donovan Mock Circulation System

Persistent Link:
http://hdl.handle.net/10150/556703
Title:
System and Method for Comparison and Training of Mechanical Circulatory Support Devices: A Patient Independent Platform Using the Total Artificial Heart and Donovan Mock Circulation System
Author:
DeCook, Katrina Jolene
Issue Date:
2015
Publisher:
The University of Arizona.
Rights:
Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
Abstract:
Mechanical circulatory support (MCS) is a viable therapy for end stage heart failure. However, despite clinical success, the ability to compare MCS devices in vitro and perform training scenarios is extremely limited. Comparative studies are limited as different devices cannot be interchanged in a patient due to the surgical nature of implant. Further, training and failure scenarios cannot be performed on patients with devices as this would subject a patient to a failure mode. A need exists for a readily available mock system that can perform comparative testing and training scenarios with MCS devices. Previously, our group has fabricated a well characterized mock circulation system consisting of a SynCardia temporary Total Artificial Heart (TAH) and Donovan Mock Circulation tank (DMC tank). Further, utilizing this system with the TAH operating in reduced output mode, a heart failure model was developed. In the present study, three ventricular assist devices (VADs) were independently attached to the heart failure model to compare device performances over a range of preloads and afterloads. In addition, specific clinical scenarios were created with the system to analyze how VAD-displayed waveforms from the system correlate with clinical scenarios. Finally, each VAD was powered off while attached to the heart failure model to compare fluid flow through the VAD in a pump-failure scenario. We demonstrated that this system can successfully be utilized to compare MCS devices (i.e. ventricular assist devices) and for successful training of patients and clinicians.
Type:
text; Electronic Thesis
Keywords:
heart failure; HQ curve; mock circulation system; training tool; ventricular assist device; Biomedical Engineering; artificial heart
Degree Name:
M.S.
Degree Level:
masters
Degree Program:
Graduate College; Biomedical Engineering
Degree Grantor:
University of Arizona
Advisor:
Slepian, Marvin J.

Full metadata record

DC FieldValue Language
dc.language.isoen_USen
dc.titleSystem and Method for Comparison and Training of Mechanical Circulatory Support Devices: A Patient Independent Platform Using the Total Artificial Heart and Donovan Mock Circulation Systemen_US
dc.creatorDeCook, Katrina Joleneen
dc.contributor.authorDeCook, Katrina Joleneen
dc.date.issued2015en
dc.publisherThe University of Arizona.en
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.en
dc.description.abstractMechanical circulatory support (MCS) is a viable therapy for end stage heart failure. However, despite clinical success, the ability to compare MCS devices in vitro and perform training scenarios is extremely limited. Comparative studies are limited as different devices cannot be interchanged in a patient due to the surgical nature of implant. Further, training and failure scenarios cannot be performed on patients with devices as this would subject a patient to a failure mode. A need exists for a readily available mock system that can perform comparative testing and training scenarios with MCS devices. Previously, our group has fabricated a well characterized mock circulation system consisting of a SynCardia temporary Total Artificial Heart (TAH) and Donovan Mock Circulation tank (DMC tank). Further, utilizing this system with the TAH operating in reduced output mode, a heart failure model was developed. In the present study, three ventricular assist devices (VADs) were independently attached to the heart failure model to compare device performances over a range of preloads and afterloads. In addition, specific clinical scenarios were created with the system to analyze how VAD-displayed waveforms from the system correlate with clinical scenarios. Finally, each VAD was powered off while attached to the heart failure model to compare fluid flow through the VAD in a pump-failure scenario. We demonstrated that this system can successfully be utilized to compare MCS devices (i.e. ventricular assist devices) and for successful training of patients and clinicians.en
dc.typetexten
dc.typeElectronic Thesisen
dc.subjectheart failureen
dc.subjectHQ curveen
dc.subjectmock circulation systemen
dc.subjecttraining toolen
dc.subjectventricular assist deviceen
dc.subjectBiomedical Engineeringen
dc.subjectartificial hearten
thesis.degree.nameM.S.en
thesis.degree.levelmastersen
thesis.degree.disciplineGraduate Collegeen
thesis.degree.disciplineBiomedical Engineeringen
thesis.degree.grantorUniversity of Arizonaen
dc.contributor.advisorSlepian, Marvin J.en
dc.contributor.committeememberCohen, Zoeen
dc.contributor.committeememberKhalpey, Zain I.en
dc.contributor.committeememberSmith, Richard G.en
dc.contributor.committeememberSlepian, Marvin J.en
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