Studies of the anticonvulsant spectrum of delta 9 - tetrahydrocannabinol in rats

Persistent Link:
http://hdl.handle.net/10150/347875
Title:
Studies of the anticonvulsant spectrum of delta 9 - tetrahydrocannabinol in rats
Author:
Reinking, Jeffrey Carl
Issue Date:
1976
Publisher:
The University of Arizona.
Rights:
Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
Abstract:
Delta 9 - tetrahydrocannabinol (Delta 9 - THC), given orally was studied for anticonvulsant activity against electroshock seizures, and for anticonvulsant activity as well as protection from lethality against subcutaneous pentylenetetrazol (PTZ), picrotoxin, and strychnine,and intraperitoneal lidocaine in rats. Delta 9 - THC in a dose-related fashion elevates the threshold for maximal electroshock seizures. A dose of 30 mg/kg of delta 9 - THC provides anticonvulsant activity against maximal PTZ seizures while the same dose does not protect against maximal seizures induced by strychnine or minimal seizures induced by electroshock, PTZ, lidocaine or picrotoxin. Further, delta 9 -THC at 30 mg/kg does not protect against lethality induced by any of the chemical convulsants used. These data indicate that delta 9 - THC has a rather narrow anticonvulsant spectrum of activity involving only maximal electroshock and PTZ seizures. In these respects, delta 9 - THC resembles phenytoin.
Type:
text; Thesis-Reproduction (electronic)
Keywords:
Tetrahydrocannabinol.; Anticonvulsants.
Degree Name:
M.S.
Degree Level:
masters
Degree Program:
Pharmacology; Graduate College
Degree Grantor:
University of Arizona

Full metadata record

DC FieldValue Language
dc.language.isoen_USen
dc.titleStudies of the anticonvulsant spectrum of delta 9 - tetrahydrocannabinol in ratsen
dc.creatorReinking, Jeffrey Carlen
dc.contributor.authorReinking, Jeffrey Carlen
dc.date.issued1976en
dc.publisherThe University of Arizona.en
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.en
dc.description.abstractDelta 9 - tetrahydrocannabinol (Delta 9 - THC), given orally was studied for anticonvulsant activity against electroshock seizures, and for anticonvulsant activity as well as protection from lethality against subcutaneous pentylenetetrazol (PTZ), picrotoxin, and strychnine,and intraperitoneal lidocaine in rats. Delta 9 - THC in a dose-related fashion elevates the threshold for maximal electroshock seizures. A dose of 30 mg/kg of delta 9 - THC provides anticonvulsant activity against maximal PTZ seizures while the same dose does not protect against maximal seizures induced by strychnine or minimal seizures induced by electroshock, PTZ, lidocaine or picrotoxin. Further, delta 9 -THC at 30 mg/kg does not protect against lethality induced by any of the chemical convulsants used. These data indicate that delta 9 - THC has a rather narrow anticonvulsant spectrum of activity involving only maximal electroshock and PTZ seizures. In these respects, delta 9 - THC resembles phenytoin.en
dc.description.noteThis item was digitized from a paper original and/or a microfilm copy. If you need higher-resolution images for any content in this item, please contact us at repository@u.library.arizona.edu.en
dc.typetexten
dc.typeThesis-Reproduction (electronic)en
dc.subjectTetrahydrocannabinol.en
dc.subjectAnticonvulsants.en
thesis.degree.nameM.S.en
thesis.degree.levelmastersen
thesis.degree.disciplinePharmacologyen
thesis.degree.disciplineGraduate Collegeen
thesis.degree.grantorUniversity of Arizonaen
dc.identifier.oclc701879168en
dc.identifier.bibrecord.b64849016en
dc.identifier.callnumberE9791 1976 130en
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