Persistent Link:
http://hdl.handle.net/10150/319877
Title:
The Biophysics of Titin in Cardiac Health and Disease
Author:
Anderson, Brian R.
Issue Date:
2014
Publisher:
The University of Arizona.
Rights:
Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
Abstract:
The giant protein titin is the third myofilament in the cardiac sarcomere. It is responsible for generating passive forces in stretched myocardium and maintaining sarcomere structure. The force generation properties of titin are determined by titin's elastic springlike elements, and this dissertation focuses on the determination of the physical properties of these springlike elements using atomic force microscopy. The primary project of this dissertation investigates the link between a single point mutation in one of titin's subdomains and arrhythmogenic cardiomyopathy.
Type:
text; Electronic Dissertation
Keywords:
ARVC; Ig; protein kinetics; Titin; Physics; AFM
Degree Name:
Ph.D.
Degree Level:
doctoral
Degree Program:
Graduate College; Physics
Degree Grantor:
University of Arizona
Advisor:
Granzier, Henk; Visscher, Koen

Full metadata record

DC FieldValue Language
dc.language.isoen_USen
dc.titleThe Biophysics of Titin in Cardiac Health and Diseaseen_US
dc.creatorAnderson, Brian R.en_US
dc.contributor.authorAnderson, Brian R.en_US
dc.date.issued2014-
dc.publisherThe University of Arizona.en_US
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.en_US
dc.description.abstractThe giant protein titin is the third myofilament in the cardiac sarcomere. It is responsible for generating passive forces in stretched myocardium and maintaining sarcomere structure. The force generation properties of titin are determined by titin's elastic springlike elements, and this dissertation focuses on the determination of the physical properties of these springlike elements using atomic force microscopy. The primary project of this dissertation investigates the link between a single point mutation in one of titin's subdomains and arrhythmogenic cardiomyopathy.en_US
dc.typetexten
dc.typeElectronic Dissertationen
dc.subjectARVCen_US
dc.subjectIgen_US
dc.subjectprotein kineticsen_US
dc.subjectTitinen_US
dc.subjectPhysicsen_US
dc.subjectAFMen_US
thesis.degree.namePh.D.en_US
thesis.degree.leveldoctoralen_US
thesis.degree.disciplineGraduate Collegeen_US
thesis.degree.disciplinePhysicsen_US
thesis.degree.grantorUniversity of Arizonaen_US
dc.contributor.advisorGranzier, Henken_US
dc.contributor.advisorVisscher, Koenen_US
dc.contributor.committeememberGranzier, Henken_US
dc.contributor.committeememberVisscher, Koenen_US
dc.contributor.committeememberLeRoy, Brianen_US
dc.contributor.committeememberManne, Srinen_US
dc.contributor.committeememberHausrath, Andrewen_US
All Items in UA Campus Repository are protected by copyright, with all rights reserved, unless otherwise indicated.