Radiation and Immunity in the Context of Cytomegalovirus and Aging

Persistent Link:
http://hdl.handle.net/10150/312509
Title:
Radiation and Immunity in the Context of Cytomegalovirus and Aging
Author:
Pugh, Jason L.
Issue Date:
2013
Publisher:
The University of Arizona.
Rights:
Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
Abstract:
The impact of ionizing radiation exposure on the immune system is dramatic and potentially lethal. The mechanism behind the radiosensitivity of immune subsets has been the concern of researchers for decades, while the long-term effects of radiation exposure in youth have been scarcely explored. The life-long impact of very prevalent latent human viruses, such as Cytomegalovirus (CMV), have recently been brought to the forefront of aging research. However, most short and long-term studies of radiation on the immune system have been performed with animals devoid of latent viruses. Here we describe an innate cause for immune subset radiosensitivity differences, and introduce a post-exposure intervention. We also describe the effects of latent CMV on acute immune sensitivity. Further, we discover that the long-term impact of radiation exposure on the immune system is dependent on whether or not latent CMV was present at the time of exposure. These findings intersect with the research fields of DNA repair, radiobiology, virology, aging, basic immunity, and stand to inform future radiation policy and research.
Type:
text; Electronic Dissertation
Keywords:
Genetics
Degree Name:
Ph.D.
Degree Level:
doctoral
Degree Program:
Graduate College; Genetics
Degree Grantor:
University of Arizona
Advisor:
Nikolich-Zugich, Janko

Full metadata record

DC FieldValue Language
dc.language.isoen_USen
dc.titleRadiation and Immunity in the Context of Cytomegalovirus and Agingen_US
dc.creatorPugh, Jason L.en_US
dc.contributor.authorPugh, Jason L.en_US
dc.date.issued2013-
dc.publisherThe University of Arizona.en_US
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.en_US
dc.description.abstractThe impact of ionizing radiation exposure on the immune system is dramatic and potentially lethal. The mechanism behind the radiosensitivity of immune subsets has been the concern of researchers for decades, while the long-term effects of radiation exposure in youth have been scarcely explored. The life-long impact of very prevalent latent human viruses, such as Cytomegalovirus (CMV), have recently been brought to the forefront of aging research. However, most short and long-term studies of radiation on the immune system have been performed with animals devoid of latent viruses. Here we describe an innate cause for immune subset radiosensitivity differences, and introduce a post-exposure intervention. We also describe the effects of latent CMV on acute immune sensitivity. Further, we discover that the long-term impact of radiation exposure on the immune system is dependent on whether or not latent CMV was present at the time of exposure. These findings intersect with the research fields of DNA repair, radiobiology, virology, aging, basic immunity, and stand to inform future radiation policy and research.en_US
dc.typetexten
dc.typeElectronic Dissertationen
dc.subjectGeneticsen_US
thesis.degree.namePh.D.en_US
thesis.degree.leveldoctoralen_US
thesis.degree.disciplineGraduate Collegeen_US
thesis.degree.disciplineGeneticsen_US
thesis.degree.grantorUniversity of Arizonaen_US
dc.contributor.advisorNikolich-Zugich, Jankoen_US
dc.contributor.committeememberNikolich-Zugich, Jankoen_US
dc.contributor.committeememberWeinert, Teden_US
dc.contributor.committeememberLimesand, Kirstenen_US
dc.contributor.committeememberBosco, Giovannien_US
All Items in UA Campus Repository are protected by copyright, with all rights reserved, unless otherwise indicated.