Simultaneous Optical and MR Imaging of Tissue Within Implanted Window Chamber: System Development and Application in Measuring Vascular Permeability

Persistent Link:
http://hdl.handle.net/10150/308901
Title:
Simultaneous Optical and MR Imaging of Tissue Within Implanted Window Chamber: System Development and Application in Measuring Vascular Permeability
Author:
Shayegan Salek, Mir Farrokh
Issue Date:
2013
Publisher:
The University of Arizona.
Rights:
Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
Abstract:
Simultaneous optical imaging and MRI of a dorsal skin-fold window chamber mouse model is investigated as a novel methodology to study the tumor microenvironment. Simultaneous imaging with two modalities allows for cross-validation of results, integration of the capabilities of the two modalities in one study and mitigation of invasive factors, such as surgery and anesthesia, in an in-vivo experiment. To make this investigation possible, three optical imaging systems were developed that operated inside the MRI scanner. One of the developed systems was applied to estimate vascular kinetic parameters of tumors in a dorsal skin-fold window chamber mouse model with simultaneous optical and MRI imaging. The target of imaging was a molecular agent that was dual labeled with both optical and MRI contrast agents. The labeling of the molecular agent, characteristics of the developed optical systems, the methodologies of measuring vascular kinetic parameters using optical imaging and MRI data, and the obtained results are described and illustrated.
Type:
text; Electronic Dissertation
Keywords:
Multimodality imaging; Simultaneous Imaging; Tumor microenvironment; Vascular Permeability; window chamber; Optical Sciences; DCE-MRI
Degree Name:
Ph.D.
Degree Level:
doctoral
Degree Program:
Graduate College; Optical Sciences
Degree Grantor:
University of Arizona
Advisor:
Gmitro, Arthur F.

Full metadata record

DC FieldValue Language
dc.language.isoen_USen_US
dc.titleSimultaneous Optical and MR Imaging of Tissue Within Implanted Window Chamber: System Development and Application in Measuring Vascular Permeabilityen_US
dc.creatorShayegan Salek, Mir Farrokhen_US
dc.contributor.authorShayegan Salek, Mir Farrokhen_US
dc.date.issued2013-
dc.publisherThe University of Arizona.en_US
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.en_US
dc.description.abstractSimultaneous optical imaging and MRI of a dorsal skin-fold window chamber mouse model is investigated as a novel methodology to study the tumor microenvironment. Simultaneous imaging with two modalities allows for cross-validation of results, integration of the capabilities of the two modalities in one study and mitigation of invasive factors, such as surgery and anesthesia, in an in-vivo experiment. To make this investigation possible, three optical imaging systems were developed that operated inside the MRI scanner. One of the developed systems was applied to estimate vascular kinetic parameters of tumors in a dorsal skin-fold window chamber mouse model with simultaneous optical and MRI imaging. The target of imaging was a molecular agent that was dual labeled with both optical and MRI contrast agents. The labeling of the molecular agent, characteristics of the developed optical systems, the methodologies of measuring vascular kinetic parameters using optical imaging and MRI data, and the obtained results are described and illustrated.en_US
dc.typetexten_US
dc.typeElectronic Dissertationen_US
dc.subjectMultimodality imagingen_US
dc.subjectSimultaneous Imagingen_US
dc.subjectTumor microenvironmenten_US
dc.subjectVascular Permeabilityen_US
dc.subjectwindow chamberen_US
dc.subjectOptical Sciencesen_US
dc.subjectDCE-MRIen_US
thesis.degree.namePh.D.en_US
thesis.degree.leveldoctoralen_US
thesis.degree.disciplineGraduate Collegeen_US
thesis.degree.disciplineOptical Sciencesen_US
thesis.degree.grantorUniversity of Arizonaen_US
dc.contributor.advisorGmitro, Arthur F.en_US
dc.contributor.committeememberGmitro, Arthur F.en_US
dc.contributor.committeememberPagel, Mark D.en_US
dc.contributor.committeememberRaghunand, Natarajanen_US
dc.contributor.committeememberClarkson, Ericen_US
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