Persistent Link:
http://hdl.handle.net/10150/297745
Title:
Metabolism of Arsenic by Mouse Embryonic Liver Tissue
Author:
Quach, Stephanie
Issue Date:
2013
Publisher:
The University of Arizona.
Rights:
Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
Abstract:
Inorganic arsenic is an environmental toxin that affects many people around the world. It is especially a problem in countries where people depend on arsenic-contaminated well water, where it has been shown to lead to various health problems, from cardiovascular disease to liver disease to cancer. While these effects have been well studied, the effects of arsenic on embryonic tissues have not. This study examined embryonic liver cell and explant tissue for the ability to metabolize inorganic arsenic. The results showed that embryonic liver cells were able to metabolize a small amount of the arsenic to dimethylarsonous acid [DMA(V)], while embryonic liver explant cultures were able to metabolize some arsenic to monomethylarsonous acid [MMA(III)] and more to DMA(V). These results show that embryonic tissues are indeed able to metabolize arsenic, and they serve the purpose of broadening the scope of understanding and research into in utero exposure to toxins like arsenic and the onset and progression of disease later in life.
Type:
text; Electronic Thesis
Degree Name:
B.S.
Degree Level:
bachelors
Degree Program:
Honors College; Molecular and Cellular Biology
Degree Grantor:
University of Arizona
Advisor:
Camenisch, Todd

Full metadata record

DC FieldValue Language
dc.language.isoenen_US
dc.titleMetabolism of Arsenic by Mouse Embryonic Liver Tissueen_US
dc.creatorQuach, Stephanieen_US
dc.contributor.authorQuach, Stephanieen_US
dc.date.issued2013-
dc.publisherThe University of Arizona.en_US
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.en_US
dc.description.abstractInorganic arsenic is an environmental toxin that affects many people around the world. It is especially a problem in countries where people depend on arsenic-contaminated well water, where it has been shown to lead to various health problems, from cardiovascular disease to liver disease to cancer. While these effects have been well studied, the effects of arsenic on embryonic tissues have not. This study examined embryonic liver cell and explant tissue for the ability to metabolize inorganic arsenic. The results showed that embryonic liver cells were able to metabolize a small amount of the arsenic to dimethylarsonous acid [DMA(V)], while embryonic liver explant cultures were able to metabolize some arsenic to monomethylarsonous acid [MMA(III)] and more to DMA(V). These results show that embryonic tissues are indeed able to metabolize arsenic, and they serve the purpose of broadening the scope of understanding and research into in utero exposure to toxins like arsenic and the onset and progression of disease later in life.en_US
dc.typetexten_US
dc.typeElectronic Thesisen_US
thesis.degree.nameB.S.en_US
thesis.degree.levelbachelorsen_US
thesis.degree.disciplineHonors Collegeen_US
thesis.degree.disciplineMolecular and Cellular Biologyen_US
thesis.degree.grantorUniversity of Arizonaen_US
dc.contributor.advisorCamenisch, Todd-
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