Persistent Link:
http://hdl.handle.net/10150/297713
Title:
Review of Apoptosis with a Connexin Emphasis
Author:
Nesbitt, Nathan Wood
Issue Date:
2013
Publisher:
The University of Arizona.
Rights:
Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
Abstract:
Gap junction proteins (connexins) are essential components in vital cellular processes such as intercellular communication. Apoptosis is the process through which cells are systematically killed and recycled to maintain healthy tissues and organs. Through a plethora of different signaling cascades connexins can directly influence the incidence of apoptosis in tissue. The relationship between connexins and apoptosis has been recognized by the scientific community, but the factors that govern this relationship remain mysterious. In some tissues connexins have been observed to promote apoptotic activity in combination with cell stressors, while in other tissues connexins prove protective against apoptosis even when cells are stressed. For instance in cancerous tissue and primary culture connexins are often found to be proapoptotic, while in healthy tissues connexins often prove anti-apoptotic when cells are subjected to stressors. In effect, connexins are dynamic proteins that have the potential to change from supporting life to supporting death based a complex interaction between the extracellular environment and internal cellular cues.
Type:
text; Electronic Thesis
Degree Name:
B.S.
Degree Level:
bachelors
Degree Program:
Honors College; Physiology
Degree Grantor:
University of Arizona
Advisor:
Burt, Janis

Full metadata record

DC FieldValue Language
dc.language.isoenen_US
dc.titleReview of Apoptosis with a Connexin Emphasisen_US
dc.creatorNesbitt, Nathan Wooden_US
dc.contributor.authorNesbitt, Nathan Wooden_US
dc.date.issued2013-
dc.publisherThe University of Arizona.en_US
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.en_US
dc.description.abstractGap junction proteins (connexins) are essential components in vital cellular processes such as intercellular communication. Apoptosis is the process through which cells are systematically killed and recycled to maintain healthy tissues and organs. Through a plethora of different signaling cascades connexins can directly influence the incidence of apoptosis in tissue. The relationship between connexins and apoptosis has been recognized by the scientific community, but the factors that govern this relationship remain mysterious. In some tissues connexins have been observed to promote apoptotic activity in combination with cell stressors, while in other tissues connexins prove protective against apoptosis even when cells are stressed. For instance in cancerous tissue and primary culture connexins are often found to be proapoptotic, while in healthy tissues connexins often prove anti-apoptotic when cells are subjected to stressors. In effect, connexins are dynamic proteins that have the potential to change from supporting life to supporting death based a complex interaction between the extracellular environment and internal cellular cues.en_US
dc.typetexten_US
dc.typeElectronic Thesisen_US
thesis.degree.nameB.S.en_US
thesis.degree.levelbachelorsen_US
thesis.degree.disciplineHonors Collegeen_US
thesis.degree.disciplinePhysiologyen_US
thesis.degree.grantorUniversity of Arizonaen_US
dc.contributor.advisorBurt, Janis-
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