Regional Cerebral Oxygen Desaturations in Coronary Artery Bypass Surgery: A Minimally Invasive Approach

Persistent Link:
http://hdl.handle.net/10150/293646
Title:
Regional Cerebral Oxygen Desaturations in Coronary Artery Bypass Surgery: A Minimally Invasive Approach
Author:
Mills, Benjamin Colin
Issue Date:
2013
Publisher:
The University of Arizona.
Rights:
Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
Abstract:
Cerebral oximetry has been shown to effectively identify declining regional cerebral oxygen saturations (rSO2) in coronary artery bypass graft (CABG) surgery. Prolonged intraoperative cerebral desaturations have been significantly associated with an increased risk of cognitive decline after CABG surgery. We compared conventional CABG to minimally invasive robotic coronary artery bypass surgery (r-CABG) using cerebral oximetry to determine the beneficial effects of the less invasive procedure. A retrospective study of 32 isolated CABG patients were treated for coronary artery disease (CAD) via conventional CABG (n=20) or r-CABG (n=12) with analysis of cerebral oximetry tracings and intraoperative data. Parameters, such as, blood loss, mean arterial pressure (MAP), partial pressure of carbon dioxide (PaCO2), cardiopulmonary bypass (CPB), and diabetes mellitus (DM) were analyzed against the area under the curve (AUC) from the cerebral oximetry tracing, an indicator of rSO2 desaturations. Many of these parameters showed statistical significance (p<0.05) between conventional CABG and r-CABG including a decreased mean AUC in the latter. In conclusion, minimally invasive r-CABG tends to show beneficial effects for patients by reducing the total mean AUC in comparison to conventional CABG, especially in the DM patient.
Type:
text; Electronic Thesis
Keywords:
Medical Pharmacology
Degree Name:
M.S.
Degree Level:
masters
Degree Program:
Graduate College; Medical Pharmacology
Degree Grantor:
University of Arizona
Advisor:
Poston, Robert S.

Full metadata record

DC FieldValue Language
dc.language.isoenen_US
dc.titleRegional Cerebral Oxygen Desaturations in Coronary Artery Bypass Surgery: A Minimally Invasive Approachen_US
dc.creatorMills, Benjamin Colinen_US
dc.contributor.authorMills, Benjamin Colinen_US
dc.date.issued2013-
dc.publisherThe University of Arizona.en_US
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.en_US
dc.description.abstractCerebral oximetry has been shown to effectively identify declining regional cerebral oxygen saturations (rSO2) in coronary artery bypass graft (CABG) surgery. Prolonged intraoperative cerebral desaturations have been significantly associated with an increased risk of cognitive decline after CABG surgery. We compared conventional CABG to minimally invasive robotic coronary artery bypass surgery (r-CABG) using cerebral oximetry to determine the beneficial effects of the less invasive procedure. A retrospective study of 32 isolated CABG patients were treated for coronary artery disease (CAD) via conventional CABG (n=20) or r-CABG (n=12) with analysis of cerebral oximetry tracings and intraoperative data. Parameters, such as, blood loss, mean arterial pressure (MAP), partial pressure of carbon dioxide (PaCO2), cardiopulmonary bypass (CPB), and diabetes mellitus (DM) were analyzed against the area under the curve (AUC) from the cerebral oximetry tracing, an indicator of rSO2 desaturations. Many of these parameters showed statistical significance (p<0.05) between conventional CABG and r-CABG including a decreased mean AUC in the latter. In conclusion, minimally invasive r-CABG tends to show beneficial effects for patients by reducing the total mean AUC in comparison to conventional CABG, especially in the DM patient.en_US
dc.typetexten_US
dc.typeElectronic Thesisen_US
dc.subjectMedical Pharmacologyen_US
thesis.degree.nameM.S.en_US
thesis.degree.levelmastersen_US
thesis.degree.disciplineGraduate Collegeen_US
thesis.degree.disciplineMedical Pharmacologyen_US
thesis.degree.grantorUniversity of Arizonaen_US
dc.contributor.advisorPoston, Robert S.en_US
dc.contributor.committeememberVanderah, Todden_US
dc.contributor.committeememberPalmer, Johnen_US
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