Effect of β-carotene supplementation in Honduran lactating mothers on serum β-carotene and retinol levels of their breast-fed infants

Persistent Link:
http://hdl.handle.net/10150/291740
Title:
Effect of β-carotene supplementation in Honduran lactating mothers on serum β-carotene and retinol levels of their breast-fed infants
Author:
Mahal, Zeenat, 1964-
Issue Date:
1997
Publisher:
The University of Arizona.
Rights:
Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
Abstract:
The objective of this study is to assess the effects of pure β-carotene supplementation in the lactating mothers on serum β-carotene and retinol levels of their breast-fed infants. Data for this study is taken from a nutritional intervention trial conducted in Tegucigalpa, Honduras. Forty five healthy, lactating mothers and their infants participated. During the intervention trial, all of the mothers took 30 mg of pure β-carotene capsules with their morning meal for three alternate days (a total of 90 mg) in the week-long trial. The mothers provided 10 milliliter of breast milk per sampling and 5 milliliter of blood per draw. Two milliliter of blood was collected from each infants during the trial. β-Carotene and retinol concentrations were quantitated in the breast milk and in the serum samples using high-performance-liquid-chromatography (HPLC). Results of the t-test confirmed that the supplementation of β-carotene to the lactating mothers has a significant effect on their breast-fed infants' serum retinol concentrations. This is reflected in the increased levels (by a ∼10 fold) of infants' serum retinol concentrations. It is also observed that there is a statistically significant increase of the β-carotene levels in the maternal breast milk and serum samples due to this β-carotene supplementation. A similar increase of retinol levels in the maternal blood samples is observed. In addition, a modest correlation between the retinol concentrations of post-supplemented maternal breast milk and the post-supplemented serum of infants, equal to or less than four months of age, is also observed. This dose-response relationship suggests that a regular supplementation of β-carotene to the lactating mothers might help their breast-fed children in harnessing the long term beneficial effects of vitamin A. (Abstract shortened by UMI.)
Type:
text; Thesis-Reproduction (electronic)
Keywords:
Health Sciences, Nutrition.
Degree Name:
M.S.
Degree Level:
masters
Degree Program:
Graduate College; Epidemiology
Degree Grantor:
University of Arizona
Advisor:
Petersen, Eskild A.

Full metadata record

DC FieldValue Language
dc.language.isoen_USen_US
dc.titleEffect of β-carotene supplementation in Honduran lactating mothers on serum β-carotene and retinol levels of their breast-fed infantsen_US
dc.creatorMahal, Zeenat, 1964-en_US
dc.contributor.authorMahal, Zeenat, 1964-en_US
dc.date.issued1997en_US
dc.publisherThe University of Arizona.en_US
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.en_US
dc.description.abstractThe objective of this study is to assess the effects of pure β-carotene supplementation in the lactating mothers on serum β-carotene and retinol levels of their breast-fed infants. Data for this study is taken from a nutritional intervention trial conducted in Tegucigalpa, Honduras. Forty five healthy, lactating mothers and their infants participated. During the intervention trial, all of the mothers took 30 mg of pure β-carotene capsules with their morning meal for three alternate days (a total of 90 mg) in the week-long trial. The mothers provided 10 milliliter of breast milk per sampling and 5 milliliter of blood per draw. Two milliliter of blood was collected from each infants during the trial. β-Carotene and retinol concentrations were quantitated in the breast milk and in the serum samples using high-performance-liquid-chromatography (HPLC). Results of the t-test confirmed that the supplementation of β-carotene to the lactating mothers has a significant effect on their breast-fed infants' serum retinol concentrations. This is reflected in the increased levels (by a ∼10 fold) of infants' serum retinol concentrations. It is also observed that there is a statistically significant increase of the β-carotene levels in the maternal breast milk and serum samples due to this β-carotene supplementation. A similar increase of retinol levels in the maternal blood samples is observed. In addition, a modest correlation between the retinol concentrations of post-supplemented maternal breast milk and the post-supplemented serum of infants, equal to or less than four months of age, is also observed. This dose-response relationship suggests that a regular supplementation of β-carotene to the lactating mothers might help their breast-fed children in harnessing the long term beneficial effects of vitamin A. (Abstract shortened by UMI.)en_US
dc.typetexten_US
dc.typeThesis-Reproduction (electronic)en_US
dc.subjectHealth Sciences, Nutrition.en_US
thesis.degree.nameM.S.en_US
thesis.degree.levelmastersen_US
thesis.degree.disciplineGraduate Collegeen_US
thesis.degree.disciplineEpidemiologyen_US
thesis.degree.grantorUniversity of Arizonaen_US
dc.contributor.advisorPetersen, Eskild A.en_US
dc.identifier.proquest1385738en_US
dc.identifier.bibrecord.b37459375en_US
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