Persistent Link:
http://hdl.handle.net/10150/291689
Title:
Disposition kinetics of Amphotericin-B in rats
Author:
Cai, Yuli, 1961-
Issue Date:
1991
Publisher:
The University of Arizona.
Rights:
Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
Abstract:
The disposition kinetics of Amphotericin-B (Am-B) were investigated in rats in three different dose groups. Each group contained four rats. The serum and urine Am-B concentrations were analyzed by reversed-phase HPLC. There were no significant differences for total body clearance and half-lives as a function of dose. Those observations suggested systemic dose-independent behavior of Am-B. However, renal clearance of Am-B decreased significantly as Am-B dose increased; whereas, no renal damage was observed during the experiment. The present studies suggested that renal clearance was dose-dependent and that there may be a saturable tubular secretion process for Am-B renal excretion.
Type:
text; Thesis-Reproduction (electronic)
Keywords:
Health Sciences, Pharmacology.; Chemistry, Pharmaceutical.
Degree Name:
M.S.
Degree Level:
masters
Degree Program:
Graduate College; Pharmaceutical Sciences
Degree Grantor:
University of Arizona
Advisor:
Mayersohn, Michael

Full metadata record

DC FieldValue Language
dc.language.isoen_USen_US
dc.titleDisposition kinetics of Amphotericin-B in ratsen_US
dc.creatorCai, Yuli, 1961-en_US
dc.contributor.authorCai, Yuli, 1961-en_US
dc.date.issued1991en_US
dc.publisherThe University of Arizona.en_US
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.en_US
dc.description.abstractThe disposition kinetics of Amphotericin-B (Am-B) were investigated in rats in three different dose groups. Each group contained four rats. The serum and urine Am-B concentrations were analyzed by reversed-phase HPLC. There were no significant differences for total body clearance and half-lives as a function of dose. Those observations suggested systemic dose-independent behavior of Am-B. However, renal clearance of Am-B decreased significantly as Am-B dose increased; whereas, no renal damage was observed during the experiment. The present studies suggested that renal clearance was dose-dependent and that there may be a saturable tubular secretion process for Am-B renal excretion.en_US
dc.typetexten_US
dc.typeThesis-Reproduction (electronic)en_US
dc.subjectHealth Sciences, Pharmacology.en_US
dc.subjectChemistry, Pharmaceutical.en_US
thesis.degree.nameM.S.en_US
thesis.degree.levelmastersen_US
thesis.degree.disciplineGraduate Collegeen_US
thesis.degree.disciplinePharmaceutical Sciencesen_US
thesis.degree.grantorUniversity of Arizonaen_US
dc.contributor.advisorMayersohn, Michaelen_US
dc.identifier.proquest1343609en_US
dc.identifier.bibrecord.b26807051en_US
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