Persistent Link:
http://hdl.handle.net/10150/291605
Title:
Disposition kinetics of amphotericin B in rats
Author:
Wu, Yuhong, 1964-
Issue Date:
1993
Publisher:
The University of Arizona.
Rights:
Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
Abstract:
Plan for the investigation of pharmacokinetics of amphotericin B (AmB) in rats. The disposition kinetics of AmB as a function of dose was characterized in this research project to improve the therapeutic usage of this drug. Male Sprague-Dawley rats were randomly divided into three different dose groups, receiving high, medium and low dose of AmB. Serum samples and urine samples were collected and assayed by HPLC. There are no significant differences for half-life, volume of distribution or systemic clearance as a function of dose. However, renal clearance decreases when the total infused dose increases. Creatinine clearance decreases significantly in the high dose group, suggesting the occurrence of nephrotoxicity. We conclude that volume of distribution and systemic clearance are linear over the dose range studied. The dose-dependent renal clearance may be due to either the nephrotoxicity associated with AmB or saturable secretion.
Type:
text; Thesis-Reproduction (electronic)
Keywords:
Health Sciences, Pharmacology.; Health Sciences, Pharmacy.
Degree Name:
M.S.
Degree Level:
masters
Degree Program:
Graduate College; Pharmaceutical Sciences
Degree Grantor:
University of Arizona
Advisor:
Chow, S.

Full metadata record

DC FieldValue Language
dc.language.isoen_USen_US
dc.titleDisposition kinetics of amphotericin B in ratsen_US
dc.creatorWu, Yuhong, 1964-en_US
dc.contributor.authorWu, Yuhong, 1964-en_US
dc.date.issued1993en_US
dc.publisherThe University of Arizona.en_US
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.en_US
dc.description.abstractPlan for the investigation of pharmacokinetics of amphotericin B (AmB) in rats. The disposition kinetics of AmB as a function of dose was characterized in this research project to improve the therapeutic usage of this drug. Male Sprague-Dawley rats were randomly divided into three different dose groups, receiving high, medium and low dose of AmB. Serum samples and urine samples were collected and assayed by HPLC. There are no significant differences for half-life, volume of distribution or systemic clearance as a function of dose. However, renal clearance decreases when the total infused dose increases. Creatinine clearance decreases significantly in the high dose group, suggesting the occurrence of nephrotoxicity. We conclude that volume of distribution and systemic clearance are linear over the dose range studied. The dose-dependent renal clearance may be due to either the nephrotoxicity associated with AmB or saturable secretion.en_US
dc.typetexten_US
dc.typeThesis-Reproduction (electronic)en_US
dc.subjectHealth Sciences, Pharmacology.en_US
dc.subjectHealth Sciences, Pharmacy.en_US
thesis.degree.nameM.S.en_US
thesis.degree.levelmastersen_US
thesis.degree.disciplineGraduate Collegeen_US
thesis.degree.disciplinePharmaceutical Sciencesen_US
thesis.degree.grantorUniversity of Arizonaen_US
dc.contributor.advisorChow, S.en_US
dc.identifier.proquest1352310en_US
dc.identifier.bibrecord.b26933305en_US
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