Solubility of quinoline in aqueous systems: Effect of pH and ionic strength

Persistent Link:
http://hdl.handle.net/10150/291584
Title:
Solubility of quinoline in aqueous systems: Effect of pH and ionic strength
Author:
Carvajal-Figueroa, Maria Teresa, 1959-
Issue Date:
1989
Publisher:
The University of Arizona.
Rights:
Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
Abstract:
Nitrogen-heterocyclic compounds are commonly found in gas waste and coal cleaning residue. Within this general compound class, quinoline is especially important because it has the potential to induce liver carcinoma and it also has a high solubility in water. The pH-solubility profile of quinoline was determined in citrate-phosphate buffer at different ionic strengths. The pKa was observed to change with ionic strength. The intrinsic solubility is always reported as a constant. However, in this study the intrinsic solubility was observed to vary with ionic strength. The solubility of quinoline is dependent on pH as well as the ionic strength. At pH values lower than the pKa (4.96), quinoline is in the protonated form (QH⁺), and enhanced solubility was observed. At pH values higher than the pKa, quinoline is in the neutral form (Q) which is the form that determines intrinsic solubility (So). So decreased with increasing ionic strength. This observation can be explained as a salting out effect. From the solubility data the apparent ionization constant, pKa, of quinoline was obtained for the different systems.
Type:
text; Thesis-Reproduction (electronic)
Keywords:
Quinoline -- Solubility.
Degree Name:
M.S.
Degree Level:
masters
Degree Program:
Graduate College; Pharmaceutical Sciences
Degree Grantor:
University of Arizona
Advisor:
Yalkowsky, Samuel H.

Full metadata record

DC FieldValue Language
dc.language.isoen_USen_US
dc.titleSolubility of quinoline in aqueous systems: Effect of pH and ionic strengthen_US
dc.creatorCarvajal-Figueroa, Maria Teresa, 1959-en_US
dc.contributor.authorCarvajal-Figueroa, Maria Teresa, 1959-en_US
dc.date.issued1989en_US
dc.publisherThe University of Arizona.en_US
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.en_US
dc.description.abstractNitrogen-heterocyclic compounds are commonly found in gas waste and coal cleaning residue. Within this general compound class, quinoline is especially important because it has the potential to induce liver carcinoma and it also has a high solubility in water. The pH-solubility profile of quinoline was determined in citrate-phosphate buffer at different ionic strengths. The pKa was observed to change with ionic strength. The intrinsic solubility is always reported as a constant. However, in this study the intrinsic solubility was observed to vary with ionic strength. The solubility of quinoline is dependent on pH as well as the ionic strength. At pH values lower than the pKa (4.96), quinoline is in the protonated form (QH⁺), and enhanced solubility was observed. At pH values higher than the pKa, quinoline is in the neutral form (Q) which is the form that determines intrinsic solubility (So). So decreased with increasing ionic strength. This observation can be explained as a salting out effect. From the solubility data the apparent ionization constant, pKa, of quinoline was obtained for the different systems.en_US
dc.typetexten_US
dc.typeThesis-Reproduction (electronic)en_US
dc.subjectQuinoline -- Solubility.en_US
thesis.degree.nameM.S.en_US
thesis.degree.levelmastersen_US
thesis.degree.disciplineGraduate Collegeen_US
thesis.degree.disciplinePharmaceutical Sciencesen_US
thesis.degree.grantorUniversity of Arizonaen_US
dc.contributor.advisorYalkowsky, Samuel H.en_US
dc.identifier.proquest1338070en_US
dc.identifier.oclc22905277en_US
dc.identifier.bibrecord.b17526413en_US
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