Cocaine detection in hair: Effect of retroviral infection, age, morphine, and alcohol

Persistent Link:
http://hdl.handle.net/10150/291477
Title:
Cocaine detection in hair: Effect of retroviral infection, age, morphine, and alcohol
Author:
Poet, Torka Sue, 1966-
Issue Date:
1991
Publisher:
The University of Arizona.
Rights:
Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
Abstract:
Factors affecting the deposition of cocaine into hair and the relationships between those concentrations, survey questionnaire results and natural killer cell activities were investigated. First, two and 18 month old mice were infected with LP-BM5, injected with cocaine, and hair cocaine content measured. There was no difference in cocaine concentration between the age groups. Retrovirally infection mice had greater amounts of cocaine in their hair. Next, a group of mice were fed an ethanol diet and injected with cocaine. There was a decrease in cocaine recovered in the hair of the ethanol-fed mice. In a group of human drug users no correlation was found between survey questionnaire answers and hair cocaine concentrations. There was a correlation between natural killer cell activity and hair cocaine concentrations. It was concluded that hair analysis for cocaine may have a place in clinical settings, but a predictive correlation between drug intake and hair concentration may not be possible.
Type:
text; Thesis-Reproduction (electronic)
Keywords:
Health Sciences, Toxicology.; Chemistry, Analytical.
Degree Name:
M.S.
Degree Level:
masters
Degree Program:
Graduate College; Pharmacology and Toxicology
Degree Grantor:
University of Arizona
Advisor:
Watson, Ronald R.

Full metadata record

DC FieldValue Language
dc.language.isoen_USen_US
dc.titleCocaine detection in hair: Effect of retroviral infection, age, morphine, and alcoholen_US
dc.creatorPoet, Torka Sue, 1966-en_US
dc.contributor.authorPoet, Torka Sue, 1966-en_US
dc.date.issued1991en_US
dc.publisherThe University of Arizona.en_US
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.en_US
dc.description.abstractFactors affecting the deposition of cocaine into hair and the relationships between those concentrations, survey questionnaire results and natural killer cell activities were investigated. First, two and 18 month old mice were infected with LP-BM5, injected with cocaine, and hair cocaine content measured. There was no difference in cocaine concentration between the age groups. Retrovirally infection mice had greater amounts of cocaine in their hair. Next, a group of mice were fed an ethanol diet and injected with cocaine. There was a decrease in cocaine recovered in the hair of the ethanol-fed mice. In a group of human drug users no correlation was found between survey questionnaire answers and hair cocaine concentrations. There was a correlation between natural killer cell activity and hair cocaine concentrations. It was concluded that hair analysis for cocaine may have a place in clinical settings, but a predictive correlation between drug intake and hair concentration may not be possible.en_US
dc.typetexten_US
dc.typeThesis-Reproduction (electronic)en_US
dc.subjectHealth Sciences, Toxicology.en_US
dc.subjectChemistry, Analytical.en_US
thesis.degree.nameM.S.en_US
thesis.degree.levelmastersen_US
thesis.degree.disciplineGraduate Collegeen_US
thesis.degree.disciplinePharmacology and Toxicologyen_US
thesis.degree.grantorUniversity of Arizonaen_US
dc.contributor.advisorWatson, Ronald R.en_US
dc.identifier.proquest1345418en_US
dc.identifier.bibrecord.b27028811en_US
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