Persistent Link:
http://hdl.handle.net/10150/291438
Title:
Analysis of lethal (1) myospheroid mutants
Author:
Salatino, Richard, 1956-
Issue Date:
1990
Publisher:
The University of Arizona.
Rights:
Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
Abstract:
I report a characterization of several alleles of the myospheroid (mys) gene which encodes the beta-chain of the Drosophils PS integrins. Genetic analysis revealed that the mysˣᴿ, mutation is antimorphic and the mysˣᴺ mutation is hypomorphic. Protein was detected on Western blots from hemizygous mysˣᴿ and mysˣᴺ animals. No integrin beta-subunit was detected in in situ immunofluorescence assays in mysˣᴿ embryos. However, antigen was detected in a small subset of muscle attachment sites in mysˣᴺ embryos. mysˣᴳ and mysˣᴮ alleles behaved, genetically, as null alleles and no protein was detected on Western blots or in immunofluorescence assays. Complementation tests between mysᵗˢ¹, mysᵗˢ³, and the other lethal mys alleles unusual results which suggest that mys may be a transvecting locus.
Type:
text; Thesis-Reproduction (electronic)
Keywords:
Biology, Molecular.; Biology, Molecular.
Degree Name:
M.S.
Degree Level:
masters
Degree Program:
Graduate College; Molecular and Cellular Biology
Degree Grantor:
University of Arizona
Advisor:
Brower, Danny L.

Full metadata record

DC FieldValue Language
dc.language.isoen_USen_US
dc.titleAnalysis of lethal (1) myospheroid mutantsen_US
dc.creatorSalatino, Richard, 1956-en_US
dc.contributor.authorSalatino, Richard, 1956-en_US
dc.date.issued1990en_US
dc.publisherThe University of Arizona.en_US
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.en_US
dc.description.abstractI report a characterization of several alleles of the myospheroid (mys) gene which encodes the beta-chain of the Drosophils PS integrins. Genetic analysis revealed that the mysˣᴿ, mutation is antimorphic and the mysˣᴺ mutation is hypomorphic. Protein was detected on Western blots from hemizygous mysˣᴿ and mysˣᴺ animals. No integrin beta-subunit was detected in in situ immunofluorescence assays in mysˣᴿ embryos. However, antigen was detected in a small subset of muscle attachment sites in mysˣᴺ embryos. mysˣᴳ and mysˣᴮ alleles behaved, genetically, as null alleles and no protein was detected on Western blots or in immunofluorescence assays. Complementation tests between mysᵗˢ¹, mysᵗˢ³, and the other lethal mys alleles unusual results which suggest that mys may be a transvecting locus.en_US
dc.typetexten_US
dc.typeThesis-Reproduction (electronic)en_US
dc.subjectBiology, Molecular.en_US
dc.subjectBiology, Molecular.en_US
thesis.degree.nameM.S.en_US
thesis.degree.levelmastersen_US
thesis.degree.disciplineGraduate Collegeen_US
thesis.degree.disciplineMolecular and Cellular Biologyen_US
thesis.degree.grantorUniversity of Arizonaen_US
dc.contributor.advisorBrower, Danny L.en_US
dc.identifier.proquest1341287en_US
dc.identifier.bibrecord.b26341621en_US
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