Persistent Link:
http://hdl.handle.net/10150/291428
Title:
Canthaxanthin and tumor growth in mice
Author:
Huang, Dennis Shihchang, 1957-
Issue Date:
1990
Publisher:
The University of Arizona.
Rights:
Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
Abstract:
Canthaxanthin (CX), a non-provitamin A carotenoid, has been shown to exert a variety of effects on cells of the immune system and to have tumor-specific cytopathic effects in vivo and in vitro. In the present study, CX was shown to inhibit the in vitro growth of three murine tumor cell lines, JB/MS melanoma, B16F10 melanoma, and PYB6 fibrosarcoma. This effect was dose-dependent up to a concentration of CX of 10⁻⁴M. In contrast, the growth of NIH-3T3 fibroblasts was enhanced following a 96 hr incubation with 10⁻⁴M CX. A dietary supplement of 1% CX retarded tumor growth in LP-BM5 retrovirus-infected female C57BL/6 mice after tumor challenge, but had no effect on tumor growth in normal, uninfected animals. Although, NK activity and T and B subpopulations were not modified by dietary CX after tumor challenge, irrespective of whether mice had been virus-infected, there was a slight enhancement of mitogen-stimulated IFN-τ production by virus-infected murine spleen cells when compared with non-infected cells. We suggest that CX has potential as a modifier of cancer cell growth, especially in situation where impairment of the immune system has occurred as a result of viral infection.
Type:
text; Thesis-Reproduction (electronic)
Keywords:
Biology, Microbiology.; Health Sciences, Nutrition.; Health Sciences, Immunology.; Health Sciences, Oncology.
Degree Name:
M.S.
Degree Level:
masters
Degree Program:
Graduate College; Microbiology and Immunology
Degree Grantor:
University of Arizona
Advisor:
Watson, Ronald R.

Full metadata record

DC FieldValue Language
dc.language.isoen_USen_US
dc.titleCanthaxanthin and tumor growth in miceen_US
dc.creatorHuang, Dennis Shihchang, 1957-en_US
dc.contributor.authorHuang, Dennis Shihchang, 1957-en_US
dc.date.issued1990en_US
dc.publisherThe University of Arizona.en_US
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.en_US
dc.description.abstractCanthaxanthin (CX), a non-provitamin A carotenoid, has been shown to exert a variety of effects on cells of the immune system and to have tumor-specific cytopathic effects in vivo and in vitro. In the present study, CX was shown to inhibit the in vitro growth of three murine tumor cell lines, JB/MS melanoma, B16F10 melanoma, and PYB6 fibrosarcoma. This effect was dose-dependent up to a concentration of CX of 10⁻⁴M. In contrast, the growth of NIH-3T3 fibroblasts was enhanced following a 96 hr incubation with 10⁻⁴M CX. A dietary supplement of 1% CX retarded tumor growth in LP-BM5 retrovirus-infected female C57BL/6 mice after tumor challenge, but had no effect on tumor growth in normal, uninfected animals. Although, NK activity and T and B subpopulations were not modified by dietary CX after tumor challenge, irrespective of whether mice had been virus-infected, there was a slight enhancement of mitogen-stimulated IFN-τ production by virus-infected murine spleen cells when compared with non-infected cells. We suggest that CX has potential as a modifier of cancer cell growth, especially in situation where impairment of the immune system has occurred as a result of viral infection.en_US
dc.typetexten_US
dc.typeThesis-Reproduction (electronic)en_US
dc.subjectBiology, Microbiology.en_US
dc.subjectHealth Sciences, Nutrition.en_US
dc.subjectHealth Sciences, Immunology.en_US
dc.subjectHealth Sciences, Oncology.en_US
thesis.degree.nameM.S.en_US
thesis.degree.levelmastersen_US
thesis.degree.disciplineGraduate Collegeen_US
thesis.degree.disciplineMicrobiology and Immunologyen_US
thesis.degree.grantorUniversity of Arizonaen_US
dc.contributor.advisorWatson, Ronald R.en_US
dc.identifier.proquest1342970en_US
dc.identifier.bibrecord.b26622403en_US
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