Disposition of indium in male Fisher-344 rats following intratracheal or oral administration of the III-V intermetallic semiconductor material, indium phosphide

Persistent Link:
http://hdl.handle.net/10150/291365
Title:
Disposition of indium in male Fisher-344 rats following intratracheal or oral administration of the III-V intermetallic semiconductor material, indium phosphide
Author:
Monteleone, Jonathan Patrick, 1966-
Issue Date:
1991
Publisher:
The University of Arizona.
Rights:
Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
Abstract:
A sensitive method measuring indium levels >1 ppb (ng/ml) in biological tissues was developed using graphite furnace atomic absorption spectrophotometry. Single oral and pulmonary exposure of uniformly sized indium phosphide particles (mean count diameter = 1.73 ± 0.85 μm) to rats at three dose levels. Indium was deposited throughout tissues after 4 days. Bone, hair, skin, liver and kidney contained the largest indium concentrations (ng Indium/gram tissue) in both studies. Total percent dose found in tissues by either route resulted in an estimated absorption of <0.5% (not including lung for pulmonary study) except in the oral low dose group. Here the percent dose found in tissues was about 5.0% of the administered dose. The lung retained >50% of the administered dose four days following intratracheal instillation. The major route of indium elimination for both oral and pulmonary studies was in the feces; >78% of the administered dose by two days following oral gavage and >26% of the administered dose following intratracheal instillation.
Type:
text; Thesis-Reproduction (electronic)
Keywords:
Health Sciences, Education.; Health Sciences, Pharmacology.; Environmental Sciences.
Degree Name:
M.S.
Degree Level:
masters
Degree Program:
Graduate College; Pharmacology and Toxicology
Degree Grantor:
University of Arizona
Advisor:
Carter, Dean E.

Full metadata record

DC FieldValue Language
dc.language.isoen_USen_US
dc.titleDisposition of indium in male Fisher-344 rats following intratracheal or oral administration of the III-V intermetallic semiconductor material, indium phosphideen_US
dc.creatorMonteleone, Jonathan Patrick, 1966-en_US
dc.contributor.authorMonteleone, Jonathan Patrick, 1966-en_US
dc.date.issued1991en_US
dc.publisherThe University of Arizona.en_US
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.en_US
dc.description.abstractA sensitive method measuring indium levels >1 ppb (ng/ml) in biological tissues was developed using graphite furnace atomic absorption spectrophotometry. Single oral and pulmonary exposure of uniformly sized indium phosphide particles (mean count diameter = 1.73 ± 0.85 μm) to rats at three dose levels. Indium was deposited throughout tissues after 4 days. Bone, hair, skin, liver and kidney contained the largest indium concentrations (ng Indium/gram tissue) in both studies. Total percent dose found in tissues by either route resulted in an estimated absorption of <0.5% (not including lung for pulmonary study) except in the oral low dose group. Here the percent dose found in tissues was about 5.0% of the administered dose. The lung retained >50% of the administered dose four days following intratracheal instillation. The major route of indium elimination for both oral and pulmonary studies was in the feces; >78% of the administered dose by two days following oral gavage and >26% of the administered dose following intratracheal instillation.en_US
dc.typetexten_US
dc.typeThesis-Reproduction (electronic)en_US
dc.subjectHealth Sciences, Education.en_US
dc.subjectHealth Sciences, Pharmacology.en_US
dc.subjectEnvironmental Sciences.en_US
thesis.degree.nameM.S.en_US
thesis.degree.levelmastersen_US
thesis.degree.disciplineGraduate Collegeen_US
thesis.degree.disciplinePharmacology and Toxicologyen_US
thesis.degree.grantorUniversity of Arizonaen_US
dc.contributor.advisorCarter, Dean E.en_US
dc.identifier.proquest1344024en_US
dc.identifier.bibrecord.b26917439en_US
All Items in UA Campus Repository are protected by copyright, with all rights reserved, unless otherwise indicated.