Persistent Link:
http://hdl.handle.net/10150/291330
Title:
Ovarian toxicity of 4-phenylcyclohexene in female B6C3F1 mice
Author:
Parola, Lisa, 1964-
Issue Date:
1991
Publisher:
The University of Arizona.
Rights:
Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
Abstract:
4-Phenylcyclohexene (4PC), a contaminant released from latex adhesives used to produce carpet, is structurally similar to the ovarian toxicant, 4-vinylcyclohexene (VCH). VCH causes depletion of primary ovarian follicles in mice. Our aim was to determine if the related compound, 4PC, also causes ovarian damage. Groups of B6C3F1 mice were given either: sesame seed oil (vehicle control), 3 mmole/kg 4PC (4PC-3), 6 mmole/kg 4PC (4PC-6), or 6 mmole/kg VCH (positive control), ip, daily for 30 days. Vaginal smears were done daily to determine the stage of estrus. On day 31, the mice were killed and the ovaries were fixed and stained. The numbers of primary and secondary follicles were significantly reduced in the VCH treated mice, but not in 4PC treatment groups. The number of estrous cycles/30 days was significantly reduced in VCH and 4PC-6 treated groups. This study suggests that although the substitution of a phenyl group (4PC) for a vinyl substituant (VCH) on the cyclohexene ring appears to eliminate the follicular loss, monitoring of the estrous cycles may be an early indication of an adverse reproductive effect for 4PC.
Type:
text; Thesis-Reproduction (electronic)
Keywords:
Environmental Sciences.
Degree Name:
M.S.
Degree Level:
masters
Degree Program:
Graduate College; Pharmacology and Toxicology
Degree Grantor:
University of Arizona
Advisor:
Sipes, I. Glenn

Full metadata record

DC FieldValue Language
dc.language.isoen_USen_US
dc.titleOvarian toxicity of 4-phenylcyclohexene in female B6C3F1 miceen_US
dc.creatorParola, Lisa, 1964-en_US
dc.contributor.authorParola, Lisa, 1964-en_US
dc.date.issued1991en_US
dc.publisherThe University of Arizona.en_US
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.en_US
dc.description.abstract4-Phenylcyclohexene (4PC), a contaminant released from latex adhesives used to produce carpet, is structurally similar to the ovarian toxicant, 4-vinylcyclohexene (VCH). VCH causes depletion of primary ovarian follicles in mice. Our aim was to determine if the related compound, 4PC, also causes ovarian damage. Groups of B6C3F1 mice were given either: sesame seed oil (vehicle control), 3 mmole/kg 4PC (4PC-3), 6 mmole/kg 4PC (4PC-6), or 6 mmole/kg VCH (positive control), ip, daily for 30 days. Vaginal smears were done daily to determine the stage of estrus. On day 31, the mice were killed and the ovaries were fixed and stained. The numbers of primary and secondary follicles were significantly reduced in the VCH treated mice, but not in 4PC treatment groups. The number of estrous cycles/30 days was significantly reduced in VCH and 4PC-6 treated groups. This study suggests that although the substitution of a phenyl group (4PC) for a vinyl substituant (VCH) on the cyclohexene ring appears to eliminate the follicular loss, monitoring of the estrous cycles may be an early indication of an adverse reproductive effect for 4PC.en_US
dc.typetexten_US
dc.typeThesis-Reproduction (electronic)en_US
dc.subjectEnvironmental Sciences.en_US
thesis.degree.nameM.S.en_US
thesis.degree.levelmastersen_US
thesis.degree.disciplineGraduate Collegeen_US
thesis.degree.disciplinePharmacology and Toxicologyen_US
thesis.degree.grantorUniversity of Arizonaen_US
dc.contributor.advisorSipes, I. Glennen_US
dc.identifier.proquest1343606en_US
dc.identifier.bibrecord.b2680699xen_US
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