Persistent Link:
http://hdl.handle.net/10150/290643
Title:
Effect of antioxidants in the elderly
Author:
Kaboudanian Ardestani, Sussan, 1960-
Issue Date:
1996
Publisher:
The University of Arizona.
Rights:
Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
Abstract:
Aging is associated with a decrease in antioxidant defence mechanisms and a decrease in dehydroepiandrosterone (DHEA) and melatonin (MLT). We measured lipid profile, lipid peroxidation, and the functional responsiveness of immune cells, in supplemented healthy elderly and aged mice. Human subjects were randomly assigned to receive a daily placebo, 1.8 mg β-carotene or antioxidant nutrients, 800 IU vitamin E plus 500 mg vitamin C plus 30 mg β-carotene plus 70 mg glutathione for 6 months. Antioxidant nutrients decreased the amount of plasma melandialdehyde and increased IL-2 production after 4 months. Also we investigated the effect of DHEA (19 μg/day), MLT (50 μg/day), or both in aged (16 months) C57BL/6 female mice. DHEA, MLT, or DHEA plus MLT increased IL-2, IFN production and decreased IL-6 and IL-10 production. Antioxidant nutrients can decrease one parameter of lipid peroxidation and improve IL-2 production in the elderly. MLT and DHEA can enhance immune function in aged mice.
Type:
text; Dissertation-Reproduction (electronic)
Keywords:
Gerontology.; Biology, Animal Physiology.; Health Sciences, Nutrition.; Health Sciences, Immunology.
Degree Name:
Ph.D.
Degree Level:
doctoral
Degree Program:
Graduate College; Nutritional Sciences
Degree Grantor:
University of Arizona
Advisor:
Watson, Ronald R.

Full metadata record

DC FieldValue Language
dc.language.isoen_USen_US
dc.titleEffect of antioxidants in the elderlyen_US
dc.creatorKaboudanian Ardestani, Sussan, 1960-en_US
dc.contributor.authorKaboudanian Ardestani, Sussan, 1960-en_US
dc.date.issued1996en_US
dc.publisherThe University of Arizona.en_US
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.en_US
dc.description.abstractAging is associated with a decrease in antioxidant defence mechanisms and a decrease in dehydroepiandrosterone (DHEA) and melatonin (MLT). We measured lipid profile, lipid peroxidation, and the functional responsiveness of immune cells, in supplemented healthy elderly and aged mice. Human subjects were randomly assigned to receive a daily placebo, 1.8 mg β-carotene or antioxidant nutrients, 800 IU vitamin E plus 500 mg vitamin C plus 30 mg β-carotene plus 70 mg glutathione for 6 months. Antioxidant nutrients decreased the amount of plasma melandialdehyde and increased IL-2 production after 4 months. Also we investigated the effect of DHEA (19 μg/day), MLT (50 μg/day), or both in aged (16 months) C57BL/6 female mice. DHEA, MLT, or DHEA plus MLT increased IL-2, IFN production and decreased IL-6 and IL-10 production. Antioxidant nutrients can decrease one parameter of lipid peroxidation and improve IL-2 production in the elderly. MLT and DHEA can enhance immune function in aged mice.en_US
dc.typetexten_US
dc.typeDissertation-Reproduction (electronic)en_US
dc.subjectGerontology.en_US
dc.subjectBiology, Animal Physiology.en_US
dc.subjectHealth Sciences, Nutrition.en_US
dc.subjectHealth Sciences, Immunology.en_US
thesis.degree.namePh.D.en_US
thesis.degree.leveldoctoralen_US
thesis.degree.disciplineGraduate Collegeen_US
thesis.degree.disciplineNutritional Sciencesen_US
thesis.degree.grantorUniversity of Arizonaen_US
dc.contributor.advisorWatson, Ronald R.en_US
dc.identifier.proquest9713447en_US
dc.identifier.bibrecord.b34463069en_US
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