Persistent Link:
http://hdl.handle.net/10150/290621
Title:
The design of group sequential clinical trials
Author:
Kittelson, John Martin
Issue Date:
1996
Publisher:
The University of Arizona.
Rights:
Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
Abstract:
Group sequential clinical trials have become the accepted method for monitoring the results of an ongoing trial. These methods allows early termination of a trial based on the results of "interim analyses" that are conducted after each of the groups of subjects are entered on the study. Existing methods for designing these types of trials are currently comprised of several different constructions, each of which addresses a different clinical setting. The purpose of this dissertation is to unify these constructions into a single framework. This is accomplished by first proposing a general algebraic family of stopping rules for group sequential designs, and then constructing a statistical interpretation of the family. Both Bayesian and frequentist approaches are included in this unification. The properties of the unified family of designs is examined, which lends insight into the similarities and differences between existing approaches to group sequential designs. This work is motivated by several clinical examples, and the clinical application of these designs is given detailed consideration. A particular example is used to illustrate the application of these methods, and to describe how they would be implemented in an ongoing monitoring program for a clinical trial.
Type:
text; Dissertation-Reproduction (electronic)
Keywords:
Biology, Biostatistics.; Statistics.
Degree Name:
Ph.D.
Degree Level:
doctoral
Degree Program:
Graduate College; Statistics
Degree Grantor:
University of Arizona
Advisor:
Emerson, Scott S.

Full metadata record

DC FieldValue Language
dc.language.isoen_USen_US
dc.titleThe design of group sequential clinical trialsen_US
dc.creatorKittelson, John Martinen_US
dc.contributor.authorKittelson, John Martinen_US
dc.date.issued1996en_US
dc.publisherThe University of Arizona.en_US
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.en_US
dc.description.abstractGroup sequential clinical trials have become the accepted method for monitoring the results of an ongoing trial. These methods allows early termination of a trial based on the results of "interim analyses" that are conducted after each of the groups of subjects are entered on the study. Existing methods for designing these types of trials are currently comprised of several different constructions, each of which addresses a different clinical setting. The purpose of this dissertation is to unify these constructions into a single framework. This is accomplished by first proposing a general algebraic family of stopping rules for group sequential designs, and then constructing a statistical interpretation of the family. Both Bayesian and frequentist approaches are included in this unification. The properties of the unified family of designs is examined, which lends insight into the similarities and differences between existing approaches to group sequential designs. This work is motivated by several clinical examples, and the clinical application of these designs is given detailed consideration. A particular example is used to illustrate the application of these methods, and to describe how they would be implemented in an ongoing monitoring program for a clinical trial.en_US
dc.typetexten_US
dc.typeDissertation-Reproduction (electronic)en_US
dc.subjectBiology, Biostatistics.en_US
dc.subjectStatistics.en_US
thesis.degree.namePh.D.en_US
thesis.degree.leveldoctoralen_US
thesis.degree.disciplineGraduate Collegeen_US
thesis.degree.disciplineStatisticsen_US
thesis.degree.grantorUniversity of Arizonaen_US
dc.contributor.advisorEmerson, Scott S.en_US
dc.identifier.proquest9713395en_US
dc.identifier.bibrecord.b34387833en_US
All Items in UA Campus Repository are protected by copyright, with all rights reserved, unless otherwise indicated.