The potentiometric determination of the formation constants of a novel class of macrocyclic polyaminocarboxylic acid ligands and the formation constants of the mercury(II)-glutathione complexes

Persistent Link:
http://hdl.handle.net/10150/290597
Title:
The potentiometric determination of the formation constants of a novel class of macrocyclic polyaminocarboxylic acid ligands and the formation constants of the mercury(II)-glutathione complexes
Author:
Oram, Paul Daniel, 1963-
Issue Date:
1996
Publisher:
The University of Arizona.
Rights:
Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
Abstract:
Potentiometric titrations were used to determine the thermodynamic formation constants of the complexes of newly synthesized macrocyclic polyaminocarboxylic acid ligands with selected metal ions. The formation constants were calculated with the help of a computer modeling program, BEST. Protonated complexes and hydroxylated complexes often coexist with the neutral complex in certain pH regions. This formation of multiple species is an important consideration in putting these ligands to practical use. It was also found that some of the complexes undergo a change in geometry when the pH of the solution is changed from acidic to basic. Electron spin resonance and UV-visible spectra confirmed these changes. The formation constants of the mercury(II)-glutathione complexes were also determined by potentiometric titrations. It was found that the previously reported value was incorrect by approximately ten orders of magnitude. The formation constants of the secondary species were also determined. These values have not been reported previously. A complete understanding of the solution chemistry of these complexes should be beneficial for understanding the metabolism of mercury(II) in living organisms.
Type:
text; Dissertation-Reproduction (electronic)
Keywords:
Chemistry, Biochemistry.; Chemistry, Inorganic.; Chemistry, Physical.
Degree Name:
Ph.D.
Degree Level:
doctoral
Degree Program:
Graduate College; Chemistry
Degree Grantor:
University of Arizona
Advisor:
Fernando, Quintus

Full metadata record

DC FieldValue Language
dc.language.isoen_USen_US
dc.titleThe potentiometric determination of the formation constants of a novel class of macrocyclic polyaminocarboxylic acid ligands and the formation constants of the mercury(II)-glutathione complexesen_US
dc.creatorOram, Paul Daniel, 1963-en_US
dc.contributor.authorOram, Paul Daniel, 1963-en_US
dc.date.issued1996en_US
dc.publisherThe University of Arizona.en_US
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.en_US
dc.description.abstractPotentiometric titrations were used to determine the thermodynamic formation constants of the complexes of newly synthesized macrocyclic polyaminocarboxylic acid ligands with selected metal ions. The formation constants were calculated with the help of a computer modeling program, BEST. Protonated complexes and hydroxylated complexes often coexist with the neutral complex in certain pH regions. This formation of multiple species is an important consideration in putting these ligands to practical use. It was also found that some of the complexes undergo a change in geometry when the pH of the solution is changed from acidic to basic. Electron spin resonance and UV-visible spectra confirmed these changes. The formation constants of the mercury(II)-glutathione complexes were also determined by potentiometric titrations. It was found that the previously reported value was incorrect by approximately ten orders of magnitude. The formation constants of the secondary species were also determined. These values have not been reported previously. A complete understanding of the solution chemistry of these complexes should be beneficial for understanding the metabolism of mercury(II) in living organisms.en_US
dc.typetexten_US
dc.typeDissertation-Reproduction (electronic)en_US
dc.subjectChemistry, Biochemistry.en_US
dc.subjectChemistry, Inorganic.en_US
dc.subjectChemistry, Physical.en_US
thesis.degree.namePh.D.en_US
thesis.degree.leveldoctoralen_US
thesis.degree.disciplineGraduate Collegeen_US
thesis.degree.disciplineChemistryen_US
thesis.degree.grantorUniversity of Arizonaen_US
dc.contributor.advisorFernando, Quintusen_US
dc.identifier.proquest9706688en_US
dc.identifier.bibrecord.b34303200en_US
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