The association of smoking and prevalent adenomatous polyp characteristics

Persistent Link:
http://hdl.handle.net/10150/282804
Title:
The association of smoking and prevalent adenomatous polyp characteristics
Author:
Reid, Mary Ellen, 1957-
Issue Date:
1998
Publisher:
The University of Arizona.
Rights:
Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
Abstract:
We assessed the relationship of cigarette smoking to the location, size, and histology of prevalent adenomatous colorectal polyps detected among 1429 participants, all adenoma patients, in a randomized trial testing the effects of a high (13.5 g/day) versus low (2 g/day) wheat bran fiber intervention on adenoma recurrence. Participants had a complete qualifying colonoscopy with at least one histologically confirmed adenomatous polyp 3 mm or larger. Location, size and histology of the baseline adenoma(s) were recorded. Cigarette smoking was evaluated at baseline through a self-administered questionnaire. Among the study participants, 66% had a history of ever smoking and 14% were current smokers. Compared to never smokers, those in the upper tertile of pack-years of smoking had a lower, non-significant risk of having one or more of their adenomas in the proximal colon (OR = 0.79; 95% CI = 0.53-1.16) and a lower risk of having one or more of their adenomas of villous histology (OR = 0.63; 95% CI = 0.43-0.94). Individuals in the upper tertile of pack-years of smoking were more likely to have a large (>1 cm) adenoma (OR = 1.27; 95% CI = 0.91-1.76) but no dose-response was observed. These results suggest that among adenoma patients, those who are exposed to cigarette smoking are more likely to have distal adenomas versus adenomas found only in the proximal colon. Exposure to cigarette smoke is a predictor of non-villous as opposed to villous adenomas and is not associated with adenoma size. These data describe correlations of adenoma characteristics among adenoma patients; they do not refer to the probability of adenoma presence.
Type:
text; Dissertation-Reproduction (electronic)
Keywords:
Health Sciences, Public Health.
Degree Name:
Ph.D.
Degree Level:
doctoral
Degree Program:
Graduate College; Epidemiology
Degree Grantor:
University of Arizona
Advisor:
Lebowitz, Michael

Full metadata record

DC FieldValue Language
dc.language.isoen_USen_US
dc.titleThe association of smoking and prevalent adenomatous polyp characteristicsen_US
dc.creatorReid, Mary Ellen, 1957-en_US
dc.contributor.authorReid, Mary Ellen, 1957-en_US
dc.date.issued1998en_US
dc.publisherThe University of Arizona.en_US
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.en_US
dc.description.abstractWe assessed the relationship of cigarette smoking to the location, size, and histology of prevalent adenomatous colorectal polyps detected among 1429 participants, all adenoma patients, in a randomized trial testing the effects of a high (13.5 g/day) versus low (2 g/day) wheat bran fiber intervention on adenoma recurrence. Participants had a complete qualifying colonoscopy with at least one histologically confirmed adenomatous polyp 3 mm or larger. Location, size and histology of the baseline adenoma(s) were recorded. Cigarette smoking was evaluated at baseline through a self-administered questionnaire. Among the study participants, 66% had a history of ever smoking and 14% were current smokers. Compared to never smokers, those in the upper tertile of pack-years of smoking had a lower, non-significant risk of having one or more of their adenomas in the proximal colon (OR = 0.79; 95% CI = 0.53-1.16) and a lower risk of having one or more of their adenomas of villous histology (OR = 0.63; 95% CI = 0.43-0.94). Individuals in the upper tertile of pack-years of smoking were more likely to have a large (>1 cm) adenoma (OR = 1.27; 95% CI = 0.91-1.76) but no dose-response was observed. These results suggest that among adenoma patients, those who are exposed to cigarette smoking are more likely to have distal adenomas versus adenomas found only in the proximal colon. Exposure to cigarette smoke is a predictor of non-villous as opposed to villous adenomas and is not associated with adenoma size. These data describe correlations of adenoma characteristics among adenoma patients; they do not refer to the probability of adenoma presence.en_US
dc.typetexten_US
dc.typeDissertation-Reproduction (electronic)en_US
dc.subjectHealth Sciences, Public Health.en_US
thesis.degree.namePh.D.en_US
thesis.degree.leveldoctoralen_US
thesis.degree.disciplineGraduate Collegeen_US
thesis.degree.disciplineEpidemiologyen_US
thesis.degree.grantorUniversity of Arizonaen_US
dc.contributor.advisorLebowitz, Michaelen_US
dc.identifier.proquest9912106en_US
dc.identifier.bibrecord.b39123054en_US
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