Persistent Link:
http://hdl.handle.net/10150/282227
Title:
STRUCTURES AND SYNTHESIS OF BIOLOGICALLY ACTIVE COMPOUNDS
Author:
Kriek, George Robert
Issue Date:
1980
Publisher:
The University of Arizona.
Rights:
Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
Abstract:
Part I deals with the structure determination of five organic compounds by X-ray diffraction methods: the diacetate of the sesquiterpene voleneol, which in spite of having five chiral centers, was isolated from a plant as the racemate; two 1,4-dithiin 1,1,4,4-tetroxides, one an herbicide and the other a microbiocide; bouvardin, a bicyclic hexapeptide with anti-tumor activity; and a tripeptide that is an intermediate in a synthesis of the anti-tumor agent deoxybouvardin and which contains a novel hydrogen bond. Part II details efforts to synthesize deoxybouvardin. Compounds synthesized include the corresponding monocyclic hexapeptide (which shows no anti-tumor activity) and various precursors to the 14-membered ring of deoxybouvardin.
Type:
text; Dissertation-Reproduction (electronic)
Keywords:
Biological products -- Analysis.; Terpenes -- Testing.; Peptides -- Synthesis.; Oxides -- Testing.
Degree Name:
Ph.D.
Degree Level:
doctoral
Degree Program:
Graduate College; Chemistry
Degree Grantor:
University of Arizona

Full metadata record

DC FieldValue Language
dc.language.isoen_USen_US
dc.titleSTRUCTURES AND SYNTHESIS OF BIOLOGICALLY ACTIVE COMPOUNDSen_US
dc.creatorKriek, George Roberten_US
dc.contributor.authorKriek, George Roberten_US
dc.date.issued1980en_US
dc.publisherThe University of Arizona.en_US
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.en_US
dc.description.abstractPart I deals with the structure determination of five organic compounds by X-ray diffraction methods: the diacetate of the sesquiterpene voleneol, which in spite of having five chiral centers, was isolated from a plant as the racemate; two 1,4-dithiin 1,1,4,4-tetroxides, one an herbicide and the other a microbiocide; bouvardin, a bicyclic hexapeptide with anti-tumor activity; and a tripeptide that is an intermediate in a synthesis of the anti-tumor agent deoxybouvardin and which contains a novel hydrogen bond. Part II details efforts to synthesize deoxybouvardin. Compounds synthesized include the corresponding monocyclic hexapeptide (which shows no anti-tumor activity) and various precursors to the 14-membered ring of deoxybouvardin.en_US
dc.typetexten_US
dc.typeDissertation-Reproduction (electronic)en_US
dc.subjectBiological products -- Analysis.en_US
dc.subjectTerpenes -- Testing.en_US
dc.subjectPeptides -- Synthesis.en_US
dc.subjectOxides -- Testing.en_US
thesis.degree.namePh.D.en_US
thesis.degree.leveldoctoralen_US
thesis.degree.disciplineGraduate Collegeen_US
thesis.degree.disciplineChemistryen_US
thesis.degree.grantorUniversity of Arizonaen_US
dc.identifier.proquest8017802en_US
dc.identifier.oclc7536858en_US
dc.identifier.bibrecord.b13420902en_US
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