Characterization of arteries and tissue engineered vascular grafts using experimental and finite element models

Persistent Link:
http://hdl.handle.net/10150/280739
Title:
Characterization of arteries and tissue engineered vascular grafts using experimental and finite element models
Author:
Rigby, Paul Howard
Issue Date:
2004
Publisher:
The University of Arizona.
Rights:
Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
Abstract:
In this dissertation, a methodology for comparing large arteries and tissue engineered vascular grafts is presented. This methodology is based on general porohyperelastic transport swelling theory (PHETS). Suites of experiments are introduced to determine material and transport properties of each vessel. These properties include elasticity, permeability, diffusivity, and convection coefficient. Finite element models (FEMs) were then used to model investigate arterial wall fluid flow and mobile species transport under quasi-static and pulsatile conditions. Rabbit carotid arteries were compared to rabbit aortas. The carotid was more elastic and permeable then the aorta. The pulsatile fluid wall flux was very different from the quasi-static and pulsatile in vivo conditions in these vessels. Tissue engineered vascular grafts (TEVGs) were fabricated in a bioreactor using high and low wall shear stress conditions. The elevated stiffness of ePTFE TEVGs significantly affects the fluid and species transport under both quasi-static and pulsatile conditions. A repeating influx/efflux condition developed in the large arteries and TEVGs during pulsatile pressurization. These conditions provide fluid/species transport pathways in arteries and TEVGs in pulsatile environments. The theoretical basis for ABAQUS FEMs coupled convection/diffusion of neutral species and water was developed. This will allow the analysis of mobile species concentration and flux in complex FEMs of soft biological structures. The theory and FEMs should also be useful in the study of vascular diseases, TEVG development, and drug transport in soft tissues.
Type:
text; Dissertation-Reproduction (electronic)
Keywords:
Engineering, Biomedical.
Degree Name:
Ph.D.
Degree Level:
doctoral
Degree Program:
Graduate College; Biomedical Engineering
Degree Grantor:
University of Arizona
Advisor:
Simon, Bruce R.

Full metadata record

DC FieldValue Language
dc.language.isoen_USen_US
dc.titleCharacterization of arteries and tissue engineered vascular grafts using experimental and finite element modelsen_US
dc.creatorRigby, Paul Howarden_US
dc.contributor.authorRigby, Paul Howarden_US
dc.date.issued2004en_US
dc.publisherThe University of Arizona.en_US
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.en_US
dc.description.abstractIn this dissertation, a methodology for comparing large arteries and tissue engineered vascular grafts is presented. This methodology is based on general porohyperelastic transport swelling theory (PHETS). Suites of experiments are introduced to determine material and transport properties of each vessel. These properties include elasticity, permeability, diffusivity, and convection coefficient. Finite element models (FEMs) were then used to model investigate arterial wall fluid flow and mobile species transport under quasi-static and pulsatile conditions. Rabbit carotid arteries were compared to rabbit aortas. The carotid was more elastic and permeable then the aorta. The pulsatile fluid wall flux was very different from the quasi-static and pulsatile in vivo conditions in these vessels. Tissue engineered vascular grafts (TEVGs) were fabricated in a bioreactor using high and low wall shear stress conditions. The elevated stiffness of ePTFE TEVGs significantly affects the fluid and species transport under both quasi-static and pulsatile conditions. A repeating influx/efflux condition developed in the large arteries and TEVGs during pulsatile pressurization. These conditions provide fluid/species transport pathways in arteries and TEVGs in pulsatile environments. The theoretical basis for ABAQUS FEMs coupled convection/diffusion of neutral species and water was developed. This will allow the analysis of mobile species concentration and flux in complex FEMs of soft biological structures. The theory and FEMs should also be useful in the study of vascular diseases, TEVG development, and drug transport in soft tissues.en_US
dc.typetexten_US
dc.typeDissertation-Reproduction (electronic)en_US
dc.subjectEngineering, Biomedical.en_US
thesis.degree.namePh.D.en_US
thesis.degree.leveldoctoralen_US
thesis.degree.disciplineGraduate Collegeen_US
thesis.degree.disciplineBiomedical Engineeringen_US
thesis.degree.grantorUniversity of Arizonaen_US
dc.contributor.advisorSimon, Bruce R.en_US
dc.identifier.proquest3158144en_US
dc.identifier.bibrecord.b48138022en_US
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