Relationship of perioperative hyperglycemia and major infections in cardiac surgery patients

Persistent Link:
http://hdl.handle.net/10150/280565
Title:
Relationship of perioperative hyperglycemia and major infections in cardiac surgery patients
Author:
Pear, Suzanne Marie
Issue Date:
2004
Publisher:
The University of Arizona.
Rights:
Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
Abstract:
Two of the major infectious complications of cardiac surgery are pneumonia and surgical site infections of the sternum and graft harvest site. These postoperative adverse events significantly increase patient morbidity, mortality and cost associated with coronary artery bypass graft operations. Pre-existing diabetes mellitus is commonly considered one of the primary risk factors for development of these major infections. However, most of the previous cardiac surgery risk factor studies have not considered the role perioperative stress hyperglycemia may play in initiating these complications. The primary hypothesis of this retrospective descriptive cohort study was that perioperative stress hyperglycemia (defined as either perioperative serum glucose threshold ≥250 mg/dL or perioperative serum glucose change ≥50 mg/dL) is an independent risk factor for the composite outcome of postoperative infections, including pneumonia and surgical site infections of the sternum and harvest site. The relationship of stress hyperglycemia to the individual infection outcomes was also examined. The secondary study hypothesis was that stress hyperglycemia increases resource utilization as excess days of care. The setting was a tertiary care federal medical facility in the southwestern United States, and the study cohort involved 1285 male military veterans.
Type:
text; Dissertation-Reproduction (electronic)
Keywords:
Health Sciences, Medicine and Surgery.; Health Sciences, Public Health.; Health Sciences, Health Care Management.
Degree Name:
Ph.D.
Degree Level:
doctoral
Degree Program:
Graduate College; Public Health
Degree Grantor:
University of Arizona
Advisor:
Lebowitz, Michael D.

Full metadata record

DC FieldValue Language
dc.language.isoen_USen_US
dc.titleRelationship of perioperative hyperglycemia and major infections in cardiac surgery patientsen_US
dc.creatorPear, Suzanne Marieen_US
dc.contributor.authorPear, Suzanne Marieen_US
dc.date.issued2004en_US
dc.publisherThe University of Arizona.en_US
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.en_US
dc.description.abstractTwo of the major infectious complications of cardiac surgery are pneumonia and surgical site infections of the sternum and graft harvest site. These postoperative adverse events significantly increase patient morbidity, mortality and cost associated with coronary artery bypass graft operations. Pre-existing diabetes mellitus is commonly considered one of the primary risk factors for development of these major infections. However, most of the previous cardiac surgery risk factor studies have not considered the role perioperative stress hyperglycemia may play in initiating these complications. The primary hypothesis of this retrospective descriptive cohort study was that perioperative stress hyperglycemia (defined as either perioperative serum glucose threshold ≥250 mg/dL or perioperative serum glucose change ≥50 mg/dL) is an independent risk factor for the composite outcome of postoperative infections, including pneumonia and surgical site infections of the sternum and harvest site. The relationship of stress hyperglycemia to the individual infection outcomes was also examined. The secondary study hypothesis was that stress hyperglycemia increases resource utilization as excess days of care. The setting was a tertiary care federal medical facility in the southwestern United States, and the study cohort involved 1285 male military veterans.en_US
dc.typetexten_US
dc.typeDissertation-Reproduction (electronic)en_US
dc.subjectHealth Sciences, Medicine and Surgery.en_US
dc.subjectHealth Sciences, Public Health.en_US
dc.subjectHealth Sciences, Health Care Management.en_US
thesis.degree.namePh.D.en_US
thesis.degree.leveldoctoralen_US
thesis.degree.disciplineGraduate Collegeen_US
thesis.degree.disciplinePublic Healthen_US
thesis.degree.grantorUniversity of Arizonaen_US
dc.contributor.advisorLebowitz, Michael D.en_US
dc.identifier.proquest3132248en_US
dc.identifier.bibrecord.b46708042en_US
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