Effect of a cereal fiber intervention on nutrient intake and adenoma recurrence in the Wheat Bran Fiber trial

Persistent Link:
http://hdl.handle.net/10150/279861
Title:
Effect of a cereal fiber intervention on nutrient intake and adenoma recurrence in the Wheat Bran Fiber trial
Author:
Jacobs, Elizabeth Theresa
Issue Date:
2001
Publisher:
The University of Arizona.
Rights:
Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
Abstract:
The Wheat Bran Fiber (WBF) trial was a double-blind, placebo-controlled intervention trial in which participants were randomized to receive a cereal fiber supplement of either 2.0 or 13.5 g/day to determine whether the high-fiber supplement could decrease the risk of recurrent colorectal adenomas. No effect of the supplement was observed. However, there are several issues in the WBF trial that remain to be explored, including whether there were non-supplemental dietary changes throughout the course of the study, and whether baseline fiber intake or the amount of fiber consumed by participants during the trial were associated with adenoma recurrence. With regard to changes in nutrient intake, no significant differences were found between the high-fiber and low-fiber groups at any of the three time points. Therefore, data from the two treatment groups were combined to assess longitudinal change during the study. Participants significantly decreased their fat intake during the trial, but the intake of most micronutrients was increased. With regard to food groups, the number of servings of fruits, vegetables, and dairy products did not change appreciably, while servings from the fat and meat groups were significantly decreased. The intake of cereals, breads and crackers increased significantly, possibly due to the addition of the cereal supplement to the diet. Furthermore, it is likely that the increase in micronutrient intake can be attributed to the consumption of the study supplement. The next issue was whether baseline fiber intake was associated with risk of adenoma recurrence. No association was found between the amount of fiber consumed at baseline and adenoma recurrence, nor did baseline fiber intake modify the effect of treatment group. Finally, it was important to determine whether the amount of fiber consumed during the WBF trial, regardless of treatment group, was associated with adenoma recurrence. There were no significant associations between amount of.
Type:
text; Dissertation-Reproduction (electronic)
Keywords:
Health Sciences, Nutrition.
Degree Name:
Ph.D.
Degree Level:
doctoral
Degree Program:
Graduate College; Interdisciplinary Program inNutritional Science
Degree Grantor:
University of Arizona
Advisor:
Giuliano, Anna R.; Martinez, Maria Elena

Full metadata record

DC FieldValue Language
dc.language.isoen_USen_US
dc.titleEffect of a cereal fiber intervention on nutrient intake and adenoma recurrence in the Wheat Bran Fiber trialen_US
dc.creatorJacobs, Elizabeth Theresaen_US
dc.contributor.authorJacobs, Elizabeth Theresaen_US
dc.date.issued2001en_US
dc.publisherThe University of Arizona.en_US
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.en_US
dc.description.abstractThe Wheat Bran Fiber (WBF) trial was a double-blind, placebo-controlled intervention trial in which participants were randomized to receive a cereal fiber supplement of either 2.0 or 13.5 g/day to determine whether the high-fiber supplement could decrease the risk of recurrent colorectal adenomas. No effect of the supplement was observed. However, there are several issues in the WBF trial that remain to be explored, including whether there were non-supplemental dietary changes throughout the course of the study, and whether baseline fiber intake or the amount of fiber consumed by participants during the trial were associated with adenoma recurrence. With regard to changes in nutrient intake, no significant differences were found between the high-fiber and low-fiber groups at any of the three time points. Therefore, data from the two treatment groups were combined to assess longitudinal change during the study. Participants significantly decreased their fat intake during the trial, but the intake of most micronutrients was increased. With regard to food groups, the number of servings of fruits, vegetables, and dairy products did not change appreciably, while servings from the fat and meat groups were significantly decreased. The intake of cereals, breads and crackers increased significantly, possibly due to the addition of the cereal supplement to the diet. Furthermore, it is likely that the increase in micronutrient intake can be attributed to the consumption of the study supplement. The next issue was whether baseline fiber intake was associated with risk of adenoma recurrence. No association was found between the amount of fiber consumed at baseline and adenoma recurrence, nor did baseline fiber intake modify the effect of treatment group. Finally, it was important to determine whether the amount of fiber consumed during the WBF trial, regardless of treatment group, was associated with adenoma recurrence. There were no significant associations between amount of.en_US
dc.typetexten_US
dc.typeDissertation-Reproduction (electronic)en_US
dc.subjectHealth Sciences, Nutrition.en_US
thesis.degree.namePh.D.en_US
thesis.degree.leveldoctoralen_US
thesis.degree.disciplineGraduate Collegeen_US
thesis.degree.disciplineInterdisciplinary Program inNutritional Scienceen_US
thesis.degree.grantorUniversity of Arizonaen_US
dc.contributor.advisorGiuliano, Anna R.en_US
dc.contributor.advisorMartinez, Maria Elenaen_US
dc.identifier.proquest3031368en_US
dc.identifier.bibrecord.b42285938en_US
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