Glycosylations via in situ formation of glycosyl iodides from glycosyl bromides

Persistent Link:
http://hdl.handle.net/10150/278767
Title:
Glycosylations via in situ formation of glycosyl iodides from glycosyl bromides
Author:
Lam, Son Ngoc
Issue Date:
2001
Publisher:
The University of Arizona.
Rights:
Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
Abstract:
Glycosyl iodides have proven to be highly efficient and stereospecific glycosyl donors. Unfortunately with such high reactivity, they possess short shelf lives. Glycosyl bromides, on the other hand, are more robust than their iodo-counterparts. But, glycosylations using glycosyl bromides in the absence of Lewis acid catalysts are slow. Recently, we have demonstrated conditions augmenting glycosylations involving glycosyl bromides to levels matching the efficiency and stereospecificity of glycosyl iodides. Results of our studies will be discussed.
Type:
text; Thesis-Reproduction (electronic)
Keywords:
Chemistry, Organic.
Degree Name:
M.S.
Degree Level:
masters
Degree Program:
Graduate College; Chemistry
Degree Grantor:
University of Arizona
Advisor:
Gervay-Hague, Jacquelyn

Full metadata record

DC FieldValue Language
dc.language.isoen_USen_US
dc.titleGlycosylations via in situ formation of glycosyl iodides from glycosyl bromidesen_US
dc.creatorLam, Son Ngocen_US
dc.contributor.authorLam, Son Ngocen_US
dc.date.issued2001en_US
dc.publisherThe University of Arizona.en_US
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.en_US
dc.description.abstractGlycosyl iodides have proven to be highly efficient and stereospecific glycosyl donors. Unfortunately with such high reactivity, they possess short shelf lives. Glycosyl bromides, on the other hand, are more robust than their iodo-counterparts. But, glycosylations using glycosyl bromides in the absence of Lewis acid catalysts are slow. Recently, we have demonstrated conditions augmenting glycosylations involving glycosyl bromides to levels matching the efficiency and stereospecificity of glycosyl iodides. Results of our studies will be discussed.en_US
dc.typetexten_US
dc.typeThesis-Reproduction (electronic)en_US
dc.subjectChemistry, Organic.en_US
thesis.degree.nameM.S.en_US
thesis.degree.levelmastersen_US
thesis.degree.disciplineGraduate Collegeen_US
thesis.degree.disciplineChemistryen_US
thesis.degree.grantorUniversity of Arizonaen_US
dc.contributor.advisorGervay-Hague, Jacquelynen_US
dc.identifier.proquest1405050en_US
dc.identifier.bibrecord.b41939104en_US
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