Persistent Link:
http://hdl.handle.net/10150/278705
Title:
Studies on possible physiological effects of milk-borne bombesin
Author:
Adamson, Cynthia Ruth, 1956-
Issue Date:
1990
Publisher:
The University of Arizona.
Rights:
Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
Abstract:
Mammalian milk has been shown to contain bombesin-like immunoreactivity. In order to assess these peptides' physiologic significance in the developing gastrointestinal tract, we initially characterized the in vitro degradation of radiolabeled bombesin by intestinal luminal flush. When these studies indicated survival of bombesin in the luminal flush, we performed in vivo studies to determine if enteral administration of bombesin affects the intestinal luminal content of trypsin and protein in 12-14 day old rats. Our results showed a significant elevation of total protein and luminal tryptic content in the bombesin treated group when compared to controls. These results indicate a possible physiologic role for bombesin-like peptides in the early development of the gastrointestinal tract.
Type:
text; Thesis-Reproduction (electronic)
Keywords:
Health Sciences, Nutrition.
Degree Name:
M.S.
Degree Level:
masters
Degree Program:
Graduate College
Degree Grantor:
University of Arizona
Advisor:
Koldovsky, Otakar

Full metadata record

DC FieldValue Language
dc.language.isoen_USen_US
dc.titleStudies on possible physiological effects of milk-borne bombesinen_US
dc.creatorAdamson, Cynthia Ruth, 1956-en_US
dc.contributor.authorAdamson, Cynthia Ruth, 1956-en_US
dc.date.issued1990en_US
dc.publisherThe University of Arizona.en_US
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.en_US
dc.description.abstractMammalian milk has been shown to contain bombesin-like immunoreactivity. In order to assess these peptides' physiologic significance in the developing gastrointestinal tract, we initially characterized the in vitro degradation of radiolabeled bombesin by intestinal luminal flush. When these studies indicated survival of bombesin in the luminal flush, we performed in vivo studies to determine if enteral administration of bombesin affects the intestinal luminal content of trypsin and protein in 12-14 day old rats. Our results showed a significant elevation of total protein and luminal tryptic content in the bombesin treated group when compared to controls. These results indicate a possible physiologic role for bombesin-like peptides in the early development of the gastrointestinal tract.en_US
dc.typetexten_US
dc.typeThesis-Reproduction (electronic)en_US
dc.subjectHealth Sciences, Nutrition.en_US
thesis.degree.nameM.S.en_US
thesis.degree.levelmastersen_US
thesis.degree.disciplineGraduate Collegeen_US
thesis.degree.grantorUniversity of Arizonaen_US
dc.contributor.advisorKoldovsky, Otakaren_US
dc.identifier.proquest1342950en_US
dc.identifier.bibrecord.b26621551en_US
All Items in UA Campus Repository are protected by copyright, with all rights reserved, unless otherwise indicated.