Alpha-6 beta-1 and alpha-6 beta-4 integrin expression and the vascularization of human prostate tumor xenografts

Persistent Link:
http://hdl.handle.net/10150/278603
Title:
Alpha-6 beta-1 and alpha-6 beta-4 integrin expression and the vascularization of human prostate tumor xenografts
Author:
McCandless, John Richard, 1954-
Issue Date:
1997
Publisher:
The University of Arizona.
Rights:
Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
Abstract:
Growth and metastasis of tumors appear to be dependent on the ability of tumor cells to recruit blood vessels. Integrins are a class of cell adhesion molecules that may have a role in angiogenesis. In this study the effect of the expression of two integrins, α6β1 and α6β4, on microvessel density in human prostate tumor xenografts in SCID mice was evaluated. Five methods (one-person count, two-person count, digital analysis of immunostained tissues, and digital analysis of vascular corrosion casts) were used to measure microvessel density. Results indicate that alpha6 integrin expression correlates negatively with tumor vessel density. and with tumor cell proliferation but not the extent of the tumor burden. β4 integrin expression does not appear to affect tumor vessel density, tumor cell proliferation, nor tumor burden. Comparison of methods of quantitation suggest that computer-assisted vessel counting may offer advantages over optical counting or computer-assisted area measurement.
Type:
text; Thesis-Reproduction (electronic)
Keywords:
Chemistry, Biochemistry.; Health Sciences, Oncology.
Degree Name:
M.S.
Degree Level:
masters
Degree Program:
Graduate College; Biochemistry
Degree Grantor:
University of Arizona
Advisor:
Cress, Anne

Full metadata record

DC FieldValue Language
dc.language.isoen_USen_US
dc.titleAlpha-6 beta-1 and alpha-6 beta-4 integrin expression and the vascularization of human prostate tumor xenograftsen_US
dc.creatorMcCandless, John Richard, 1954-en_US
dc.contributor.authorMcCandless, John Richard, 1954-en_US
dc.date.issued1997en_US
dc.publisherThe University of Arizona.en_US
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.en_US
dc.description.abstractGrowth and metastasis of tumors appear to be dependent on the ability of tumor cells to recruit blood vessels. Integrins are a class of cell adhesion molecules that may have a role in angiogenesis. In this study the effect of the expression of two integrins, α6β1 and α6β4, on microvessel density in human prostate tumor xenografts in SCID mice was evaluated. Five methods (one-person count, two-person count, digital analysis of immunostained tissues, and digital analysis of vascular corrosion casts) were used to measure microvessel density. Results indicate that alpha6 integrin expression correlates negatively with tumor vessel density. and with tumor cell proliferation but not the extent of the tumor burden. β4 integrin expression does not appear to affect tumor vessel density, tumor cell proliferation, nor tumor burden. Comparison of methods of quantitation suggest that computer-assisted vessel counting may offer advantages over optical counting or computer-assisted area measurement.en_US
dc.typetexten_US
dc.typeThesis-Reproduction (electronic)en_US
dc.subjectChemistry, Biochemistry.en_US
dc.subjectHealth Sciences, Oncology.en_US
thesis.degree.nameM.S.en_US
thesis.degree.levelmastersen_US
thesis.degree.disciplineGraduate Collegeen_US
thesis.degree.disciplineBiochemistryen_US
thesis.degree.grantorUniversity of Arizonaen_US
dc.contributor.advisorCress, Anneen_US
dc.identifier.proquest1385743en_US
dc.identifier.bibrecord.b37464681en_US
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