The effect of pentylenetetrazol kindling on the somatostatin cell population in the rat hippocampus

Persistent Link:
http://hdl.handle.net/10150/278383
Title:
The effect of pentylenetetrazol kindling on the somatostatin cell population in the rat hippocampus
Author:
Amend, Diane Lisa, 1964-
Issue Date:
1990
Publisher:
The University of Arizona.
Rights:
Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
Abstract:
The kindling model of epilepsy in animals has become a widely used tool in the study of convulsive mechanisms. A recent interest in the role of somatostatin (SS) in epileptic brains has produced a small body of literature, but few insights into the function of SS in seizures. Two experiments utilizing a chemical model of kindling were used. Experiment 1 using a high dose of pentylenetetrazol (PTZ) (30mg/kg) and experiment 2 using a subseizure dose of PTZ (20mg/kg). Behavioral results of experiment 1 showed an increase in seizure sensitivity over the 2 month course of the study but failed immunostaining confounded any anatomical localization of SS. Behavioral results of experiment 2 yielded no significant difference between control and experimental animals but showed both qualitative differences and a decreased number of SS cells in the experimental group. The results of these studies make few predictions about the role of SS in seizure activity or in the kindling model of epilepsy and it is painfully obvious that more work needs to be done in this realm.
Type:
text; Thesis-Reproduction (electronic)
Keywords:
Psychology, Experimental.; Psychology, Physiological.
Degree Name:
M.A.
Degree Level:
masters
Degree Program:
Graduate College
Degree Grantor:
University of Arizona
Advisor:
Hsiao, Sigmund

Full metadata record

DC FieldValue Language
dc.language.isoen_USen_US
dc.titleThe effect of pentylenetetrazol kindling on the somatostatin cell population in the rat hippocampusen_US
dc.creatorAmend, Diane Lisa, 1964-en_US
dc.contributor.authorAmend, Diane Lisa, 1964-en_US
dc.date.issued1990en_US
dc.publisherThe University of Arizona.en_US
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.en_US
dc.description.abstractThe kindling model of epilepsy in animals has become a widely used tool in the study of convulsive mechanisms. A recent interest in the role of somatostatin (SS) in epileptic brains has produced a small body of literature, but few insights into the function of SS in seizures. Two experiments utilizing a chemical model of kindling were used. Experiment 1 using a high dose of pentylenetetrazol (PTZ) (30mg/kg) and experiment 2 using a subseizure dose of PTZ (20mg/kg). Behavioral results of experiment 1 showed an increase in seizure sensitivity over the 2 month course of the study but failed immunostaining confounded any anatomical localization of SS. Behavioral results of experiment 2 yielded no significant difference between control and experimental animals but showed both qualitative differences and a decreased number of SS cells in the experimental group. The results of these studies make few predictions about the role of SS in seizure activity or in the kindling model of epilepsy and it is painfully obvious that more work needs to be done in this realm.en_US
dc.typetexten_US
dc.typeThesis-Reproduction (electronic)en_US
dc.subjectPsychology, Experimental.en_US
dc.subjectPsychology, Physiological.en_US
thesis.degree.nameM.A.en_US
thesis.degree.levelmastersen_US
thesis.degree.disciplineGraduate Collegeen_US
thesis.degree.grantorUniversity of Arizonaen_US
dc.contributor.advisorHsiao, Sigmunden_US
dc.identifier.proquest1342638en_US
dc.identifier.bibrecord.b26592101en_US
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