Terminal-functionalized poly-t-butyl acrylates via living anionic polymerization

Persistent Link:
http://hdl.handle.net/10150/278374
Title:
Terminal-functionalized poly-t-butyl acrylates via living anionic polymerization
Author:
Mollberg, William Carl, 1967-
Issue Date:
1993
Publisher:
The University of Arizona.
Rights:
Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
Abstract:
Block copolymers were made containing peptides coupled to a hydrophobic regions that could be cleaved to obtain a hydrophilic region, similar to globular proteins. These polymers were synthesized by anionic polymerization of t-butyl acrylate followed by coupling with polypeptides. Anionic polymerization allowed control of molecular weight, polydispersity as well as end groups of the polymer. The polymer was terminated with a carboxylic acid or a primary amine, the desired end groups needed to couple this polymer to peptides by conventional peptide coupling reactions. Upon hydrolysis of the esters, the resulting hydrophilic-hydrophobic polymer may be used to act as specific channels through lipid membranes, to increase the solubility of peptides in hydrophilic and hydrophobic solvents or to modify particle growth of inorganic salts.
Type:
text; Thesis-Reproduction (electronic)
Keywords:
Chemistry, Organic.; Chemistry, Polymer.
Degree Name:
M.S.
Degree Level:
masters
Degree Program:
Graduate College; Chemistry
Degree Grantor:
University of Arizona
Advisor:
Hall, H. K., Jr.

Full metadata record

DC FieldValue Language
dc.language.isoen_USen_US
dc.titleTerminal-functionalized poly-t-butyl acrylates via living anionic polymerizationen_US
dc.creatorMollberg, William Carl, 1967-en_US
dc.contributor.authorMollberg, William Carl, 1967-en_US
dc.date.issued1993en_US
dc.publisherThe University of Arizona.en_US
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.en_US
dc.description.abstractBlock copolymers were made containing peptides coupled to a hydrophobic regions that could be cleaved to obtain a hydrophilic region, similar to globular proteins. These polymers were synthesized by anionic polymerization of t-butyl acrylate followed by coupling with polypeptides. Anionic polymerization allowed control of molecular weight, polydispersity as well as end groups of the polymer. The polymer was terminated with a carboxylic acid or a primary amine, the desired end groups needed to couple this polymer to peptides by conventional peptide coupling reactions. Upon hydrolysis of the esters, the resulting hydrophilic-hydrophobic polymer may be used to act as specific channels through lipid membranes, to increase the solubility of peptides in hydrophilic and hydrophobic solvents or to modify particle growth of inorganic salts.en_US
dc.typetexten_US
dc.typeThesis-Reproduction (electronic)en_US
dc.subjectChemistry, Organic.en_US
dc.subjectChemistry, Polymer.en_US
thesis.degree.nameM.S.en_US
thesis.degree.levelmastersen_US
thesis.degree.disciplineGraduate Collegeen_US
thesis.degree.disciplineChemistryen_US
thesis.degree.grantorUniversity of Arizonaen_US
dc.contributor.advisorHall, H. K., Jr.en_US
dc.identifier.proquest1356784en_US
dc.identifier.bibrecord.b3143597xen_US
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