The attachment of quinolone based antibiotics to metallic biomaterials

Persistent Link:
http://hdl.handle.net/10150/278347
Title:
The attachment of quinolone based antibiotics to metallic biomaterials
Author:
Eftekharzadeh, Shirin, 1967-
Issue Date:
1993
Publisher:
The University of Arizona.
Rights:
Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
Abstract:
A simple and effective technique for the deposition of ciprofloxacin HCl salt onto pore coated Ti-6Al-4V alloy rods has been investigated for the prevention of infection in orthopedic applications. This technique involves the electrophoretic deposition of negatively charged ciprofloxacin particles as well as the precipitation of ciprofloxacin anions on positively biased rods. Experimental variables such as applied voltage, coating time, and pH of the antibiotic solution have been investigated in terms of the amount of deposited antibiotic, the morphology of antibiotic coating, the rate of release of deposited ciprofloxacin and the antibacterial activity of the coated samples against Staph aureus and Staph epidermidis.
Type:
text; Thesis-Reproduction (electronic)
Keywords:
Chemistry, Pharmaceutical.; Engineering, Biomedical.; Engineering, Materials Science.
Degree Name:
M.S.
Degree Level:
masters
Degree Program:
Graduate College
Degree Grantor:
University of Arizona
Advisor:
Raghavan, Srini

Full metadata record

DC FieldValue Language
dc.language.isoen_USen_US
dc.titleThe attachment of quinolone based antibiotics to metallic biomaterialsen_US
dc.creatorEftekharzadeh, Shirin, 1967-en_US
dc.contributor.authorEftekharzadeh, Shirin, 1967-en_US
dc.date.issued1993en_US
dc.publisherThe University of Arizona.en_US
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.en_US
dc.description.abstractA simple and effective technique for the deposition of ciprofloxacin HCl salt onto pore coated Ti-6Al-4V alloy rods has been investigated for the prevention of infection in orthopedic applications. This technique involves the electrophoretic deposition of negatively charged ciprofloxacin particles as well as the precipitation of ciprofloxacin anions on positively biased rods. Experimental variables such as applied voltage, coating time, and pH of the antibiotic solution have been investigated in terms of the amount of deposited antibiotic, the morphology of antibiotic coating, the rate of release of deposited ciprofloxacin and the antibacterial activity of the coated samples against Staph aureus and Staph epidermidis.en_US
dc.typetexten_US
dc.typeThesis-Reproduction (electronic)en_US
dc.subjectChemistry, Pharmaceutical.en_US
dc.subjectEngineering, Biomedical.en_US
dc.subjectEngineering, Materials Science.en_US
thesis.degree.nameM.S.en_US
thesis.degree.levelmastersen_US
thesis.degree.disciplineGraduate Collegeen_US
thesis.degree.grantorUniversity of Arizonaen_US
dc.contributor.advisorRaghavan, Srinien_US
dc.identifier.proquest1353133en_US
dc.identifier.bibrecord.b27952009en_US
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