Persistent Link:
http://hdl.handle.net/10150/278344
Title:
Crystal size manipulation of acetaminophen via recrystallization
Author:
Pandey, Rajiv, 1967-
Issue Date:
1993
Publisher:
The University of Arizona.
Rights:
Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
Abstract:
The crystal size distribution (CSD) of any material determines its end use. Consequently, comminution processes are used to transform material from one size distribution to another. Often, recrystallization from solution is one of the processes used. Recently, a novel recrystallization process named the GAS process was developed to mill compounds that were thermally labile and insoluble in supercritical fluids. CSD could be manipulated using this process. To further illustrate the applicability of this process, size manipulation studies of acetaminophen (a widely available drug) were performed. The aim of this work was to produce crystals in the mass mean size range from 5mum to 50mum, and identify the conditions for producing the desired size distribution. A modified GAS process and a liquid anti-solvent (LAS) process were also investigated. Together with acetaminophen-butanol, other systems studied were aspirin-methanol and benzoic acid-methanol.
Type:
text; Thesis-Reproduction (electronic)
Keywords:
Chemistry, Organic.; Chemistry, Pharmaceutical.; Engineering, Chemical.
Degree Name:
M.S.
Degree Level:
masters
Degree Program:
Graduate College
Degree Grantor:
University of Arizona
Advisor:
Randolph, Alan D.

Full metadata record

DC FieldValue Language
dc.language.isoen_USen_US
dc.titleCrystal size manipulation of acetaminophen via recrystallizationen_US
dc.creatorPandey, Rajiv, 1967-en_US
dc.contributor.authorPandey, Rajiv, 1967-en_US
dc.date.issued1993en_US
dc.publisherThe University of Arizona.en_US
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.en_US
dc.description.abstractThe crystal size distribution (CSD) of any material determines its end use. Consequently, comminution processes are used to transform material from one size distribution to another. Often, recrystallization from solution is one of the processes used. Recently, a novel recrystallization process named the GAS process was developed to mill compounds that were thermally labile and insoluble in supercritical fluids. CSD could be manipulated using this process. To further illustrate the applicability of this process, size manipulation studies of acetaminophen (a widely available drug) were performed. The aim of this work was to produce crystals in the mass mean size range from 5mum to 50mum, and identify the conditions for producing the desired size distribution. A modified GAS process and a liquid anti-solvent (LAS) process were also investigated. Together with acetaminophen-butanol, other systems studied were aspirin-methanol and benzoic acid-methanol.en_US
dc.typetexten_US
dc.typeThesis-Reproduction (electronic)en_US
dc.subjectChemistry, Organic.en_US
dc.subjectChemistry, Pharmaceutical.en_US
dc.subjectEngineering, Chemical.en_US
thesis.degree.nameM.S.en_US
thesis.degree.levelmastersen_US
thesis.degree.disciplineGraduate Collegeen_US
thesis.degree.grantorUniversity of Arizonaen_US
dc.contributor.advisorRandolph, Alan D.en_US
dc.identifier.proquest1353127en_US
dc.identifier.bibrecord.b27688732en_US
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