Characterization of a Carcharhinus plumbeus immunoglobulin heavy chain gene

Persistent Link:
http://hdl.handle.net/10150/278329
Title:
Characterization of a Carcharhinus plumbeus immunoglobulin heavy chain gene
Author:
Thomas, Cameron Culver Hovey, 1963-
Issue Date:
1993
Publisher:
The University of Arizona.
Rights:
Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
Abstract:
Toward developing a comprehensive understanding of the molecular origins and changes to the recombining segmental antibody gene, I submit the present examination of the changes in immunoglobulin heavy chain coding segments over the 180-million year span separating carcharine from horned sharks. In this study, nucleic acid sequences from Carcharhinus plumbeus (sandbar shark) immunoglobulin heavy chain constant and post-Joining regions are given along with a restriction map showing the arrangement of these components within a single genomic heavy chain fragment. These sequences and map are compared with those from the horned shark, Heterodontus francisci and the nurse shark, Ginglymostoma cirratum. Shark immunoglobulin nucleic acid segments are also compared with known sequences of rat and skate, and corresponding amino acid sequences aligned with those of toad, chicken, mouse and man.
Type:
text; Thesis-Reproduction (electronic)
Keywords:
Biology, Molecular.; Biology, Microbiology.; Health Sciences, Immunology.
Degree Name:
M.S.
Degree Level:
masters
Degree Program:
Graduate College
Degree Grantor:
University of Arizona
Advisor:
Marchalonis, John J.

Full metadata record

DC FieldValue Language
dc.language.isoen_USen_US
dc.titleCharacterization of a Carcharhinus plumbeus immunoglobulin heavy chain geneen_US
dc.creatorThomas, Cameron Culver Hovey, 1963-en_US
dc.contributor.authorThomas, Cameron Culver Hovey, 1963-en_US
dc.date.issued1993en_US
dc.publisherThe University of Arizona.en_US
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.en_US
dc.description.abstractToward developing a comprehensive understanding of the molecular origins and changes to the recombining segmental antibody gene, I submit the present examination of the changes in immunoglobulin heavy chain coding segments over the 180-million year span separating carcharine from horned sharks. In this study, nucleic acid sequences from Carcharhinus plumbeus (sandbar shark) immunoglobulin heavy chain constant and post-Joining regions are given along with a restriction map showing the arrangement of these components within a single genomic heavy chain fragment. These sequences and map are compared with those from the horned shark, Heterodontus francisci and the nurse shark, Ginglymostoma cirratum. Shark immunoglobulin nucleic acid segments are also compared with known sequences of rat and skate, and corresponding amino acid sequences aligned with those of toad, chicken, mouse and man.en_US
dc.typetexten_US
dc.typeThesis-Reproduction (electronic)en_US
dc.subjectBiology, Molecular.en_US
dc.subjectBiology, Microbiology.en_US
dc.subjectHealth Sciences, Immunology.en_US
thesis.degree.nameM.S.en_US
thesis.degree.levelmastersen_US
thesis.degree.disciplineGraduate Collegeen_US
thesis.degree.grantorUniversity of Arizonaen_US
dc.contributor.advisorMarchalonis, John J.en_US
dc.identifier.proquest1353096en_US
dc.identifier.bibrecord.b27588208en_US
All Items in UA Campus Repository are protected by copyright, with all rights reserved, unless otherwise indicated.