The effects of serotonergic disruption on the locomotor response induced by cocaine, phencyclidine, and a phencyclidine analog

Persistent Link:
http://hdl.handle.net/10150/278216
Title:
The effects of serotonergic disruption on the locomotor response induced by cocaine, phencyclidine, and a phencyclidine analog
Author:
Simms, Debra Kay, 1959-
Issue Date:
1990
Publisher:
The University of Arizona.
Rights:
Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
Abstract:
This study assessed the involvement of serotonergic systems in the locomotor-stimulating effects of cocaine, phencyclidine (PCP), and the PCP analog, N- (1-(2-benzo(b)thiophenyl)cyclohexyl) piperidine (BTCP). Central serotonin (5-HT) activity was disrupted in rats with para-chloroamphetamine (p-CA), or ritanserin pretreatment, and by lesioning of the medial raphe (MR) and dorsal raphe (DR) nuclei. P-CA potentiated cocaine- and PCP- but not BTCP-induced hyperactivity. Ritanserin enhanced PCP hyperlocomotion and attenuated caffeine hyperactivity, but failed to alter cocaine and BTCP hyperlocomotion. MR lesions, but not DR lesions, dramatically increased spontaneous activity and potentiated the hyperlocomotion of cocaine, BTCP, and caffeine but not of PCP. This differential sensitivity to 5-HT disruption may reflect the relative importance of 5-HT systems in mediating the dopamine-dependent actions of these drugs. These results are discussed in relation to the neurochemical bases of drug reinforcement and schizophrenia.
Type:
text; Thesis-Reproduction (electronic)
Keywords:
Biology, Neuroscience.; Psychology, Psychobiology.; Health Sciences, Pharmacology.
Degree Name:
M.A.
Degree Level:
masters
Degree Program:
Graduate College
Degree Grantor:
University of Arizona
Advisor:
French, Edward D.; Nadel, Lynn

Full metadata record

DC FieldValue Language
dc.language.isoen_USen_US
dc.titleThe effects of serotonergic disruption on the locomotor response induced by cocaine, phencyclidine, and a phencyclidine analogen_US
dc.creatorSimms, Debra Kay, 1959-en_US
dc.contributor.authorSimms, Debra Kay, 1959-en_US
dc.date.issued1990en_US
dc.publisherThe University of Arizona.en_US
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.en_US
dc.description.abstractThis study assessed the involvement of serotonergic systems in the locomotor-stimulating effects of cocaine, phencyclidine (PCP), and the PCP analog, N- (1-(2-benzo(b)thiophenyl)cyclohexyl) piperidine (BTCP). Central serotonin (5-HT) activity was disrupted in rats with para-chloroamphetamine (p-CA), or ritanserin pretreatment, and by lesioning of the medial raphe (MR) and dorsal raphe (DR) nuclei. P-CA potentiated cocaine- and PCP- but not BTCP-induced hyperactivity. Ritanserin enhanced PCP hyperlocomotion and attenuated caffeine hyperactivity, but failed to alter cocaine and BTCP hyperlocomotion. MR lesions, but not DR lesions, dramatically increased spontaneous activity and potentiated the hyperlocomotion of cocaine, BTCP, and caffeine but not of PCP. This differential sensitivity to 5-HT disruption may reflect the relative importance of 5-HT systems in mediating the dopamine-dependent actions of these drugs. These results are discussed in relation to the neurochemical bases of drug reinforcement and schizophrenia.en_US
dc.typetexten_US
dc.typeThesis-Reproduction (electronic)en_US
dc.subjectBiology, Neuroscience.en_US
dc.subjectPsychology, Psychobiology.en_US
dc.subjectHealth Sciences, Pharmacology.en_US
thesis.degree.nameM.A.en_US
thesis.degree.levelmastersen_US
thesis.degree.disciplineGraduate Collegeen_US
thesis.degree.grantorUniversity of Arizonaen_US
dc.contributor.advisorFrench, Edward D.en_US
dc.contributor.advisorNadel, Lynnen_US
dc.identifier.proquest1342008en_US
dc.identifier.bibrecord.b26475455en_US
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