Long term reproductive organ and gonadotropin changes in female B6C3F1 mice following administration of the ovotoxin 4-vinylcyclohexene

Persistent Link:
http://hdl.handle.net/10150/278086
Title:
Long term reproductive organ and gonadotropin changes in female B6C3F1 mice following administration of the ovotoxin 4-vinylcyclohexene
Author:
Douds, Deborah Parker, 1965-
Issue Date:
1992
Publisher:
The University of Arizona.
Rights:
Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
Abstract:
4-Vinylcyclohexene (VCH) is released during rubber manufacture as an environmental contaminant. It causes destruction of ovarian follicles and ovarian cancer in mice. To determine its long term effects on the female reproductive system, female B6C3F1 mice were administered sesame seed oil or VCH (800 mg/kg) ip daily for 30 days. Mice were killed when in diestrus at 30, 60, 120, 240, or 360 days after VCH administration. Ovaries and uteri were weighed and ovaries prepared for histology. Primary and secondary follicles were counted and FSH determined by RIA. The number of estrous cycles differed from controls in the 30 day group. Uterine weight differed in the 30, 60, and 360 day groups. Primary follicles, secondary follicles and ovarian weight decreased in the VCH groups. FSH increased in the 240 and 360 day VCH groups. These studies indicate that VCH causes a dramatic and permanent reduction in ovarian follicles with a reduction in ovarian weight the most obvious indicator of follicle destruction.
Type:
text; Thesis-Reproduction (electronic)
Keywords:
Health Sciences, Toxicology.; Biology, Animal Physiology.
Degree Name:
M.S.
Degree Level:
masters
Degree Program:
Graduate College
Degree Grantor:
University of Arizona
Advisor:
Sipes, I. Glenn

Full metadata record

DC FieldValue Language
dc.language.isoen_USen_US
dc.titleLong term reproductive organ and gonadotropin changes in female B6C3F1 mice following administration of the ovotoxin 4-vinylcyclohexeneen_US
dc.creatorDouds, Deborah Parker, 1965-en_US
dc.contributor.authorDouds, Deborah Parker, 1965-en_US
dc.date.issued1992en_US
dc.publisherThe University of Arizona.en_US
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.en_US
dc.description.abstract4-Vinylcyclohexene (VCH) is released during rubber manufacture as an environmental contaminant. It causes destruction of ovarian follicles and ovarian cancer in mice. To determine its long term effects on the female reproductive system, female B6C3F1 mice were administered sesame seed oil or VCH (800 mg/kg) ip daily for 30 days. Mice were killed when in diestrus at 30, 60, 120, 240, or 360 days after VCH administration. Ovaries and uteri were weighed and ovaries prepared for histology. Primary and secondary follicles were counted and FSH determined by RIA. The number of estrous cycles differed from controls in the 30 day group. Uterine weight differed in the 30, 60, and 360 day groups. Primary follicles, secondary follicles and ovarian weight decreased in the VCH groups. FSH increased in the 240 and 360 day VCH groups. These studies indicate that VCH causes a dramatic and permanent reduction in ovarian follicles with a reduction in ovarian weight the most obvious indicator of follicle destruction.en_US
dc.typetexten_US
dc.typeThesis-Reproduction (electronic)en_US
dc.subjectHealth Sciences, Toxicology.en_US
dc.subjectBiology, Animal Physiology.en_US
thesis.degree.nameM.S.en_US
thesis.degree.levelmastersen_US
thesis.degree.disciplineGraduate Collegeen_US
thesis.degree.grantorUniversity of Arizonaen_US
dc.contributor.advisorSipes, I. Glennen_US
dc.identifier.proquest1348008en_US
dc.identifier.bibrecord.b27553243en_US
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