Spontaneous congenital heart malformations in the Sprague-Dawley rat

Persistent Link:
http://hdl.handle.net/10150/278074
Title:
Spontaneous congenital heart malformations in the Sprague-Dawley rat
Author:
Johnson, Paula Denise, 1959-
Issue Date:
1992
Publisher:
The University of Arizona.
Rights:
Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
Abstract:
The spontaneous rate of congenital cardiac defects in the commonly used Sprague-Dawley rat has not been extensively researched. The incidence of general congenital defects has been studied thoroughly and reported as very low incidence in this rat. Teratology studies using mammalian models are of increasing importance as the number of environmental contaminants increases. It is essential to know if the spontaneous congenital cardiac defect rate of this most common mammalian model in order to plan statistically appropriate research protocols. Using a thorough and detailed method of evaluating the structure of the Sprague-Dawley fetal rat heart, 624 fetal rat hearts were examined at term, just prior of delivery. The overall incidence of spontaneous congenital cardiac defects is 2.3%. This is similar to the incidence in man and thus enhances the suitability of the Sprague-Dawley rat as a small mammalian model for research into cardiac teratogenesis.
Type:
text; Thesis-Reproduction (electronic)
Keywords:
Agriculture, Animal Pathology.; Health Sciences, Pathology.; Biology, Veterinary Science.
Degree Name:
M.S.
Degree Level:
masters
Degree Program:
Graduate College
Degree Grantor:
University of Arizona
Advisor:
Dawson, Brenda V.

Full metadata record

DC FieldValue Language
dc.language.isoen_USen_US
dc.titleSpontaneous congenital heart malformations in the Sprague-Dawley raten_US
dc.creatorJohnson, Paula Denise, 1959-en_US
dc.contributor.authorJohnson, Paula Denise, 1959-en_US
dc.date.issued1992en_US
dc.publisherThe University of Arizona.en_US
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.en_US
dc.description.abstractThe spontaneous rate of congenital cardiac defects in the commonly used Sprague-Dawley rat has not been extensively researched. The incidence of general congenital defects has been studied thoroughly and reported as very low incidence in this rat. Teratology studies using mammalian models are of increasing importance as the number of environmental contaminants increases. It is essential to know if the spontaneous congenital cardiac defect rate of this most common mammalian model in order to plan statistically appropriate research protocols. Using a thorough and detailed method of evaluating the structure of the Sprague-Dawley fetal rat heart, 624 fetal rat hearts were examined at term, just prior of delivery. The overall incidence of spontaneous congenital cardiac defects is 2.3%. This is similar to the incidence in man and thus enhances the suitability of the Sprague-Dawley rat as a small mammalian model for research into cardiac teratogenesis.en_US
dc.typetexten_US
dc.typeThesis-Reproduction (electronic)en_US
dc.subjectAgriculture, Animal Pathology.en_US
dc.subjectHealth Sciences, Pathology.en_US
dc.subjectBiology, Veterinary Science.en_US
thesis.degree.nameM.S.en_US
thesis.degree.levelmastersen_US
thesis.degree.disciplineGraduate Collegeen_US
thesis.degree.grantorUniversity of Arizonaen_US
dc.contributor.advisorDawson, Brenda V.en_US
dc.identifier.proquest1347576en_US
dc.identifier.bibrecord.b27474665en_US
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