Persistent Link:
http://hdl.handle.net/10150/277981
Title:
Modeling the distribution of chylomicron cholesterol in the body
Author:
Siddiq, Ajmal, 1963-
Issue Date:
1991
Publisher:
The University of Arizona.
Rights:
Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
Abstract:
A physiologically-based multi-compartment model has been developed which makes a priori predictions of the chylomicron cholesterol distribution in the body of a rat. The model considers each organ to be a separate compartment which interacts with all the other organs/compartments through the blood stream. A particle approach has been used since chylomicron cholesterol distribution is regulated more by the particle concentrations than cholesterol concentrations. The chylomicron cholesterol distribution is coupled to the triglyceride contents of the particle. Unsteady nonlinear differential equations have been developed by making mass balances over all the compartments, and the numerical solution of these dynamic model equations is outlined. Finally, this multi-compartment model was used to predict the distribution of chylomicron cholesterol after a bolus injection of chylomicrons or their continuous infusion into the blood. The model results were then compared with the existing literature data points for such systems.
Type:
text; Thesis-Reproduction (electronic)
Keywords:
Engineering, Biomedical.; Engineering, Chemical.; Health Sciences, Nutrition.
Degree Name:
M.S.
Degree Level:
masters
Degree Program:
Graduate College
Degree Grantor:
University of Arizona
Advisor:
Fleischman, Gregory J.

Full metadata record

DC FieldValue Language
dc.language.isoen_USen_US
dc.titleModeling the distribution of chylomicron cholesterol in the bodyen_US
dc.creatorSiddiq, Ajmal, 1963-en_US
dc.contributor.authorSiddiq, Ajmal, 1963-en_US
dc.date.issued1991en_US
dc.publisherThe University of Arizona.en_US
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.en_US
dc.description.abstractA physiologically-based multi-compartment model has been developed which makes a priori predictions of the chylomicron cholesterol distribution in the body of a rat. The model considers each organ to be a separate compartment which interacts with all the other organs/compartments through the blood stream. A particle approach has been used since chylomicron cholesterol distribution is regulated more by the particle concentrations than cholesterol concentrations. The chylomicron cholesterol distribution is coupled to the triglyceride contents of the particle. Unsteady nonlinear differential equations have been developed by making mass balances over all the compartments, and the numerical solution of these dynamic model equations is outlined. Finally, this multi-compartment model was used to predict the distribution of chylomicron cholesterol after a bolus injection of chylomicrons or their continuous infusion into the blood. The model results were then compared with the existing literature data points for such systems.en_US
dc.typetexten_US
dc.typeThesis-Reproduction (electronic)en_US
dc.subjectEngineering, Biomedical.en_US
dc.subjectEngineering, Chemical.en_US
dc.subjectHealth Sciences, Nutrition.en_US
thesis.degree.nameM.S.en_US
thesis.degree.levelmastersen_US
thesis.degree.disciplineGraduate Collegeen_US
thesis.degree.grantorUniversity of Arizonaen_US
dc.contributor.advisorFleischman, Gregory J.en_US
dc.identifier.proquest1345622en_US
dc.identifier.bibrecord.b27056193en_US
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