Plasma protein binding and blood to plasma partitioning studies of methamphetamine

Persistent Link:
http://hdl.handle.net/10150/277954
Title:
Plasma protein binding and blood to plasma partitioning studies of methamphetamine
Author:
Lal, Ritu Anilkumar, 1968-
Issue Date:
1991
Publisher:
The University of Arizona.
Rights:
Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
Abstract:
Methamphetamine is a sympathomimetic drug with CNS, cardiovascular and anorectic effects. We examined the Blood to Plasma (Blood/Plasma) partitioning and plasma protein binding (PB) of d-Methamphetamine (d-MAP), using whole rat blood. The mean Blood/Plasma ratio was around 1.2 and the fraction unbound (fᵤ) was 0.8. Further, we studied the influence of concentration, pH and the presence of 1-MAP on the Blood/Plasma ratio and PB of d-MAP. There was no significant change in the Blood/Plasma ratio and the PB values at different concentrations of d-MAP or in the presence of 1-MAP. There was a slight increase in the Blood/Plasma ratio and a slight but insignificant decrease in fᵤ with pH. The equilibrium binding constants (KA) of d-MAP with human serum albumin and α₁ -acid glycoprotein were also determined and they were found to be 213 and 2461 M⁻¹ respectively.
Type:
text; Thesis-Reproduction (electronic)
Keywords:
Health Sciences, Pharmacology.; Health Sciences, Pharmacy.
Degree Name:
M.S.
Degree Level:
masters
Degree Program:
Graduate College
Degree Grantor:
University of Arizona
Advisor:
Mayersohn, Michael

Full metadata record

DC FieldValue Language
dc.language.isoen_USen_US
dc.titlePlasma protein binding and blood to plasma partitioning studies of methamphetamineen_US
dc.creatorLal, Ritu Anilkumar, 1968-en_US
dc.contributor.authorLal, Ritu Anilkumar, 1968-en_US
dc.date.issued1991en_US
dc.publisherThe University of Arizona.en_US
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.en_US
dc.description.abstractMethamphetamine is a sympathomimetic drug with CNS, cardiovascular and anorectic effects. We examined the Blood to Plasma (Blood/Plasma) partitioning and plasma protein binding (PB) of d-Methamphetamine (d-MAP), using whole rat blood. The mean Blood/Plasma ratio was around 1.2 and the fraction unbound (fᵤ) was 0.8. Further, we studied the influence of concentration, pH and the presence of 1-MAP on the Blood/Plasma ratio and PB of d-MAP. There was no significant change in the Blood/Plasma ratio and the PB values at different concentrations of d-MAP or in the presence of 1-MAP. There was a slight increase in the Blood/Plasma ratio and a slight but insignificant decrease in fᵤ with pH. The equilibrium binding constants (KA) of d-MAP with human serum albumin and α₁ -acid glycoprotein were also determined and they were found to be 213 and 2461 M⁻¹ respectively.en_US
dc.typetexten_US
dc.typeThesis-Reproduction (electronic)en_US
dc.subjectHealth Sciences, Pharmacology.en_US
dc.subjectHealth Sciences, Pharmacy.en_US
thesis.degree.nameM.S.en_US
thesis.degree.levelmastersen_US
thesis.degree.disciplineGraduate Collegeen_US
thesis.degree.grantorUniversity of Arizonaen_US
dc.contributor.advisorMayersohn, Michaelen_US
dc.identifier.proquest1345432en_US
dc.identifier.bibrecord.b27031081en_US
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