Hepatic drug clearance of three model compounds in normal subjects and cancer patients

Persistent Link:
http://hdl.handle.net/10150/277876
Title:
Hepatic drug clearance of three model compounds in normal subjects and cancer patients
Author:
McCloskey, Thomas Michael, 1958-
Issue Date:
1991
Publisher:
The University of Arizona.
Rights:
Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
Abstract:
Hepatic drug clearance (HDC) plays a fundamental role in the metabolism and disposition of xenobiotics. Numerous methods of assessing HDC have been proposed in an effort to elucidate the genetic and extra-genetic effects upon xenobiotic biotransformation. One such method incorporates the co-administration of three model compounds to assess three unique parameters of HDC; namely, hepatic blood flow, Phase I (microsomal-mediated oxidative) metabolism, and Phase II (synthesis/conjugation) reactions. Pharmacokinetic studies of indocyanine green, antipyrine, and lorazepam were undertaken to assess each HDC parameter, respectively. This method was utilized to define differences in HDC between normal, healthy, young males and an older group with cancer.
Type:
text; Thesis-Reproduction (electronic)
Keywords:
Health Sciences, Pharmacology.
Degree Name:
M.S.
Degree Level:
masters
Degree Program:
Graduate College
Degree Grantor:
University of Arizona
Advisor:
Alberts, David S.

Full metadata record

DC FieldValue Language
dc.language.isoen_USen_US
dc.titleHepatic drug clearance of three model compounds in normal subjects and cancer patientsen_US
dc.creatorMcCloskey, Thomas Michael, 1958-en_US
dc.contributor.authorMcCloskey, Thomas Michael, 1958-en_US
dc.date.issued1991en_US
dc.publisherThe University of Arizona.en_US
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.en_US
dc.description.abstractHepatic drug clearance (HDC) plays a fundamental role in the metabolism and disposition of xenobiotics. Numerous methods of assessing HDC have been proposed in an effort to elucidate the genetic and extra-genetic effects upon xenobiotic biotransformation. One such method incorporates the co-administration of three model compounds to assess three unique parameters of HDC; namely, hepatic blood flow, Phase I (microsomal-mediated oxidative) metabolism, and Phase II (synthesis/conjugation) reactions. Pharmacokinetic studies of indocyanine green, antipyrine, and lorazepam were undertaken to assess each HDC parameter, respectively. This method was utilized to define differences in HDC between normal, healthy, young males and an older group with cancer.en_US
dc.typetexten_US
dc.typeThesis-Reproduction (electronic)en_US
dc.subjectHealth Sciences, Pharmacology.en_US
thesis.degree.nameM.S.en_US
thesis.degree.levelmastersen_US
thesis.degree.disciplineGraduate Collegeen_US
thesis.degree.grantorUniversity of Arizonaen_US
dc.contributor.advisorAlberts, David S.en_US
dc.identifier.proquest1343814en_US
dc.identifier.bibrecord.b26882437en_US
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