Reticuloendothelial clearance and gastrointestinal absorption of polystyrene latex particles: Possible applications to the external scanning of tumors

Persistent Link:
http://hdl.handle.net/10150/277804
Title:
Reticuloendothelial clearance and gastrointestinal absorption of polystyrene latex particles: Possible applications to the external scanning of tumors
Author:
Reynolds, William David, 1948-
Issue Date:
1990
Publisher:
The University of Arizona.
Rights:
Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
Abstract:
The use of 153Sm-incorporated polystyrene latex particles for the external image scanning of tumors was simulated in four murine strains. Reticuloendothelial blood clearance and tissue localization of 0.5 mum and 1.0 mum fluorescent PSL was evaluated in RE-competent and RE-depressed mice following IV injection and oral particle administration. Intravenous injection of PSL revealed differences in blood clearance rates and tissue distribution patterns with respect to strain and particle size; an explanation based on genetic strain derivation is offered. RE depression in the Balb/c resulted in higher circulating blood levels of both particle sizes without affecting tissue distribution patterns; the use of dissimilarly sized particles for blocking and testing resulted in dramatic decreases in organ PSL concentrations and alterations in apparent kinetic rate constants. Balb/c blood levels of orally administered particles were increased and remained temporally constant while tissue concentrations were generally lower than IV-injected levels.
Type:
text; Thesis-Reproduction (electronic)
Keywords:
Biology, Microbiology.; Biology, Animal Physiology.; Health Sciences, Pathology.
Degree Name:
M.S.
Degree Level:
masters
Degree Program:
Graduate College
Degree Grantor:
University of Arizona
Advisor:
Olson, George B.

Full metadata record

DC FieldValue Language
dc.language.isoen_USen_US
dc.titleReticuloendothelial clearance and gastrointestinal absorption of polystyrene latex particles: Possible applications to the external scanning of tumorsen_US
dc.creatorReynolds, William David, 1948-en_US
dc.contributor.authorReynolds, William David, 1948-en_US
dc.date.issued1990en_US
dc.publisherThe University of Arizona.en_US
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.en_US
dc.description.abstractThe use of 153Sm-incorporated polystyrene latex particles for the external image scanning of tumors was simulated in four murine strains. Reticuloendothelial blood clearance and tissue localization of 0.5 mum and 1.0 mum fluorescent PSL was evaluated in RE-competent and RE-depressed mice following IV injection and oral particle administration. Intravenous injection of PSL revealed differences in blood clearance rates and tissue distribution patterns with respect to strain and particle size; an explanation based on genetic strain derivation is offered. RE depression in the Balb/c resulted in higher circulating blood levels of both particle sizes without affecting tissue distribution patterns; the use of dissimilarly sized particles for blocking and testing resulted in dramatic decreases in organ PSL concentrations and alterations in apparent kinetic rate constants. Balb/c blood levels of orally administered particles were increased and remained temporally constant while tissue concentrations were generally lower than IV-injected levels.en_US
dc.typetexten_US
dc.typeThesis-Reproduction (electronic)en_US
dc.subjectBiology, Microbiology.en_US
dc.subjectBiology, Animal Physiology.en_US
dc.subjectHealth Sciences, Pathology.en_US
thesis.degree.nameM.S.en_US
thesis.degree.levelmastersen_US
thesis.degree.disciplineGraduate Collegeen_US
thesis.degree.grantorUniversity of Arizonaen_US
dc.contributor.advisorOlson, George B.en_US
dc.identifier.proquest1342984en_US
dc.identifier.bibrecord.b26623122en_US
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