Persistent Link:
http://hdl.handle.net/10150/277267
Title:
The scientific validity of the standards for 1,2-dibromoethane
Author:
Pike, Steven, 1951-
Issue Date:
1990
Publisher:
The University of Arizona.
Rights:
Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
Abstract:
1,2-Dibromoethane (DBE) is a nematocide used extensively to control fruitfly and other larvae that feed on fruit and grain and as a lead scavenger in gasoline additives. DBE is extremely toxic to animals at relatively low doses and is carcinogenic in chronic animal studies on mice and rats. The lack of good human epidermiologic data resulted in the reliance of quantitative risk assessment techniques by the Environmental Protection Agency (EPA) for severely limiting its use as a fumigant for grain in 1984, and the Occupational Safety and Health Administration (OSHA) for lowering workplace standards from 20 parts per million (ppm) to 0.1 ppm. This thesis reviews the metabolic, animal, and human studies used for the extrapolation, the mathematical models available, the assumptions made for the data and model chosen, and discusses the validity of the resultant process for setting standards for DBE exposure.
Type:
text; Thesis-Reproduction (electronic)
Keywords:
Ethylene dibromide -- Toxicology.
Degree Name:
M.S.
Degree Level:
masters
Degree Program:
Graduate College; Toxicology
Degree Grantor:
University of Arizona
Advisor:
Sipes, I. Glenn

Full metadata record

DC FieldValue Language
dc.language.isoen_USen_US
dc.titleThe scientific validity of the standards for 1,2-dibromoethaneen_US
dc.creatorPike, Steven, 1951-en_US
dc.contributor.authorPike, Steven, 1951-en_US
dc.date.issued1990en_US
dc.publisherThe University of Arizona.en_US
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.en_US
dc.description.abstract1,2-Dibromoethane (DBE) is a nematocide used extensively to control fruitfly and other larvae that feed on fruit and grain and as a lead scavenger in gasoline additives. DBE is extremely toxic to animals at relatively low doses and is carcinogenic in chronic animal studies on mice and rats. The lack of good human epidermiologic data resulted in the reliance of quantitative risk assessment techniques by the Environmental Protection Agency (EPA) for severely limiting its use as a fumigant for grain in 1984, and the Occupational Safety and Health Administration (OSHA) for lowering workplace standards from 20 parts per million (ppm) to 0.1 ppm. This thesis reviews the metabolic, animal, and human studies used for the extrapolation, the mathematical models available, the assumptions made for the data and model chosen, and discusses the validity of the resultant process for setting standards for DBE exposure.en_US
dc.typetexten_US
dc.typeThesis-Reproduction (electronic)en_US
dc.subjectEthylene dibromide -- Toxicology.en_US
thesis.degree.nameM.S.en_US
thesis.degree.levelmastersen_US
thesis.degree.disciplineGraduate Collegeen_US
thesis.degree.disciplineToxicologyen_US
thesis.degree.grantorUniversity of Arizonaen_US
dc.contributor.advisorSipes, I. Glennen_US
dc.identifier.proquest1339905en_US
dc.identifier.oclc23715711en_US
dc.identifier.bibrecord.b17665723en_US
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